Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway (Q35014590)

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English	Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway	scientific article

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Europe PubMed Central

5 August 2017

Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway (English)

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5 August 2017

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Rodrigo A. Cunha

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Rodrigo A Cunha

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Lisiane O Porciúncula

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Geanne M A Cunha

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Carla G Silva

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Jorge M A Oliveira

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Catarina R Oliveira

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1 November 2009

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5 August 2017

Journal of Neuroscience

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47

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14741-14751

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15 May 2020

Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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cAMP delays beta-amyloid (25-35) induced cell death in rat cortical neurons

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https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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Adenosine: does it have a neuroprotective role after all?

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https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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Alzheimer's disease: genes, proteins, and therapy

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https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

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beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

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https://pubmed.ncbi.nlm.nih.gov/19940169

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beta-Amyloid neurotoxicity is exacerbated during glycolysis inhibition and mitochondrial impairment in the rat hippocampus in vivo and in isolated nerve terminals: implications for Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does caffeine intake protect from Alzheimer's disease?

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https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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Signalling from adenosine receptors to mitogen-activated protein kinases

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https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine A3 receptors are located in neurons of the rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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Oligomerization and neurotoxicity of the amyloid ADan peptide implicated in familial Danish dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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Mixed-lineage kinases: a target for the prevention of neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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A focus on the synapse for neuroprotection in Alzheimer disease and other dementias

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

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https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine and brain function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte activation and reactive gliosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

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Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P38 activation mediates amyloid-beta cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute effect of beta amyloid on synchronized spontaneous Ca2+ oscillations in cultured hippocampal networks.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The key role of mitochondria in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic vulnerability in neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting adenosine A2A receptors in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective effects of caffeine: a prospective population study (the Three City Study).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid modulation of synaptic transmission and plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tirosine kinase receptor (TrkB) content in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta(1-42) reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: a quantitative analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine, adenosine receptors, memory and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta-specific Th2 cells provide cognitive and pathological benefits to Alzheimer's mice without infiltrating the CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of light, polarization and fluorescence microscopic methods for amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of synaptic proteins in the pathogenesis of disorders of the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphological and immunophenotypic microglial changes in the denervated fascia dentata of adult rats: correlation with blood-brain barrier damage and astroglial reactions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19940169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3728-09.2009

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665997&resulttype=core&format=json

15 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665997&resulttype=core&format=json

15 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665997&resulttype=core&format=json

15 May 2020

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