Emerging Alzheimer's disease therapies: inhibition of beta-secretase (Q35019434)

5 August 2017

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title

Emerging Alzheimer's disease therapies: inhibition of beta-secretase (English)

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5 August 2017

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Martin Citron

1

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5 August 2017

publication date

1 November 2002

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5 August 2017

published in

Neurobiology of Aging

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5 August 2017

volume

23

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5 August 2017

issue

6

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5 August 2017

page(s)

1017-1022

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Expression analysis of BACE2 in brain and peripheral tissues

5 August 2017

cites work

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7 January 2021

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

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7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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7 January 2021

Maturation and pro-peptide cleavage of beta-secretase

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7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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7 January 2021

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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7 January 2021

Is there a future for renin inhibitors?

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

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Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

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7 January 2021

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

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7 January 2021

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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7 January 2021

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

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7 January 2021

Protease inhibitors: current status and future prospects

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7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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7 January 2021

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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7 January 2021

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

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7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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7 January 2021

Cellular mechanisms of beta-amyloid production and secretion

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7 January 2021

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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7 January 2021

Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

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7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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7 January 2021

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Identifiers

DOI

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5 August 2017

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