T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters (Q35022108)

5 August 2017

title

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters (English)

1 reference

5 August 2017

Michael L Dustin

4

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Jay T Groves

series ordinal

5

object named as

Jay Groves

1 reference

5 August 2017

Boryana N Manz

1

1 reference

5 August 2017

Bryan L Jackson

series ordinal

2

1 reference

5 August 2017

Rebecca S Petit

series ordinal

3

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5 August 2017

language of work or name

English

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publication date

16 May 2011

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Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

published in

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5 August 2017

volume

108

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5 August 2017

issue

22

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5 August 2017

page(s)

9089-9094

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The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

5 August 2017

cites work

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TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

8 July 2018

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TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

8 July 2018

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An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

8 July 2018

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Cluster size regulates protein sorting in the immunological synapse

8 July 2018

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Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation

8 July 2018

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Variability and robustness in T cell activation from regulated heterogeneity in protein levels

8 July 2018

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Quantitative fluorescence microscopy using supported lipid bilayer standards

8 July 2018

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T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

8 July 2018

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T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation

8 July 2018

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Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist

8 July 2018

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Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module

8 July 2018

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Spatial mutation of the T cell immunological synapse

8 July 2018

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

8 July 2018

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The kinetic-segregation model: TCR triggering and beyond

8 July 2018

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T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity

8 July 2018

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Lipid rafts and their roles in T-cell activation

8 July 2018

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CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

8 July 2018

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Supported planar bilayers in studies on immune cell adhesion and communication.

8 July 2018

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8 July 2018

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Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

8 July 2018

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Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

8 July 2018

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Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation

8 July 2018

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Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies

8 July 2018

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The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107331

The immunological synapse: a molecular machine controlling T cell activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107331

Kinetics and extent of T cell activation as measured with the calcium signal

8 July 2018

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pH affects both the mechanism and the specificity of peptide binding to a class II major histocompatibility complex molecule

8 July 2018

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

8 July 2018

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Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103).

8 July 2018

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The minimal number of class II MHC-antigen complexes needed for T cell activation

8 July 2018

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Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

8 July 2018

1 reference

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Direct observation of ligand recognition by T cells.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018771108

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018771108

Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018771108

Altered TCR signaling from geometrically repatterned immunological synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018771108

Kinetic control of histidine-tagged protein surface density on supported lipid bilayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018771108

CD28 signals in the immature immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018771108

Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon

21 January 2018

1 reference

12 December 2020

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

1 reference

12 December 2020

Micropatterning fluid lipid bilayers on solid supports

1 reference

12 December 2020

The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1018771108

1 reference

5 August 2017

0 references

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5 August 2017

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