Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial (Q35023522)

5 August 2017

title

Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial (English)

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5 August 2017

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10

Ching-Hon Pui

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5 August 2017

2

Alex Sparreboom

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5 August 2017

9

John T Sandlund

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5 August 2017

11

Mary V Relling

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5 August 2017

Torben S Mikkelsen

1

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5 August 2017

Cheng Cheng

3

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5 August 2017

Yinmei Zhou

4

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5 August 2017

James M Boyett

5

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5 August 2017

Susana C Raimondi

6

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5 August 2017

John C Panetta

7

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5 August 2017

W Paul Bowman

8

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5 August 2017

William E Evans

12

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5 August 2017

language of work or name

English

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publication date

28 March 2011

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Journal of Clinical Oncology

5 August 2017

published in

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5 August 2017

volume

29

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5 August 2017

issue

13

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5 August 2017

page(s)

1771-1778

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Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells

5 August 2017

cites work

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Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia

8 July 2018

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In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile

8 July 2018

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8 July 2018

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Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics

8 July 2018

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8 July 2018

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Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group

8 July 2018

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Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate

8 July 2018

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Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia

8 July 2018

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Methotrexate cytotoxicity for L5178Y/Asn- lymphoblasts: relationship of dose and duration of exposure to tumor cell viability.

8 July 2018

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Analysis of methotrexate polyglutamate derivatives in vivo

8 July 2018

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Impact of the methotrexate administration dose on the need for intrathecal treatment in children and adolescents with anaplastic large-cell lymphoma: results of a randomized trial of the EICNHL Group

8 July 2018

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The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95.

25 October 2018

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Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis

25 October 2018

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Results of Therapy for Acute Lymphoblastic Leukemia in Black and White Children

25 October 2018

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CNS-Directed Therapy for Childhood Acute Lymphoblastic Leukemia: Childhood ALL Collaborative Group Overview of 43 Randomized Trials

25 October 2018

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A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia

25 October 2018

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De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo

25 October 2018

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Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

25 October 2018

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Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.

25 October 2018

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Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity

25 October 2018

1 reference

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Effects of methotrexate on purine and pyrimidine metabolism and cell-kinetic parameters in human malignant lymphoblasts of different lineages

25 October 2018

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Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia

25 October 2018

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12 December 2020

Evidence for negative feedback of extracellular methotrexate on blasts of acute lymphoblastic leukemia in vitro

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12 December 2020

Intermediate dose methotrexate is as effective as high dose methotrexate in preventing isolated testicular relapse in childhood acute lymphoblastic leukemia

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12 December 2020

Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy

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12 December 2020

Role of drug concentration, duration of exposure, and endogenous metabolites in determining methotrexate cytotoxicity

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12 December 2020

Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages

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12 December 2020

Randomized comparison of 36-hour intermediate-dose versus 4-hour high-dose methotrexate infusions for remission induction in relapsed childhood acute lymphoblastic leukemia

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12 December 2020

Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia

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12 December 2020

Identifiers

DOI

10.1200/JCO.2010.32.5340

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5 August 2017

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5 August 2017

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