Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway (Q35029506)

5 August 2017

Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway (English)

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5 August 2017

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1

Kumsun Cho

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5 August 2017

8

Joo-Youn Cho

1 reference

5 August 2017

Jae Yong Chung

2

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5 August 2017

Sung Kweon Cho

3

1 reference

5 August 2017

Hyun-Woo Shin

4

1 reference

5 August 2017

In-Jin Jang

5

1 reference

5 August 2017

Jong-Wan Park

6

1 reference

5 August 2017

Kyung-Sang Yu

7

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5 August 2017

language of work or name

English

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publication date

30 January 2015

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5 August 2017

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5 August 2017

5

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5 August 2017

8145

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Creative Commons Attribution 4.0 International

5 August 2017

start time

30 January 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4311245/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/srep08145

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cites work

Metformin protects rat hepatocytes against bile acid-induced apoptosis

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Management of type 2 diabetes: new and future developments in treatment

8 July 2018

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OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects.

8 July 2018

1 reference

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Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy

8 July 2018

1 reference

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Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcription in the pituitary

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311245

Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels

8 July 2018

1 reference

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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311245

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

8 July 2018

1 reference

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Activation of AMP-activated protein kinase stimulates proopiomelanocortin gene transcription in AtT20 corticotroph cells

8 July 2018

1 reference

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Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1

8 July 2018

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Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain

8 July 2018

1 reference

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The acute and chronic toxic effects of vitamin A

8 July 2018

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

8 July 2018

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Betaine in human nutrition

8 July 2018

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Adiponectin acts in the brain to decrease body weight.

8 July 2018

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Role of AMP-activated protein kinase in mechanism of metformin action

8 July 2018

1 reference

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Renal physiology of the mouse

8 July 2018

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

8 July 2018

1 reference

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Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus

8 July 2018

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Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes

21 January 2018

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Metformin decreases GnRH- and activin-induced gonadotropin secretion in rat pituitary cells: potential involvement of adenosine 5' monophosphate-activated protein kinase (PRKA).

21 January 2018

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Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.

21 January 2018

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Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome

21 January 2018

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Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones

21 January 2018

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Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons

21 January 2018

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Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats

21 January 2018

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Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

21 January 2018

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Bile Acids Affect Liver Mitochondrial Bioenergetics: Possible Relevance for Cholestasis Therapy

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25634597

12 December 2020

inferred from PubMed ID database lookup

Increased plasma levels of immunoreactive beta-endorphin and corticotropin in non-insulin-dependent diabetes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25634597

12 December 2020

inferred from PubMed ID database lookup

Hypothalamic-pituitary-adrenal axis dysregulation among diabetic outpatients

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25634597

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/SREP08145

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Dimensions Publication ID

5 August 2017

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5 August 2017

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