Pathways for the mutagenesis of 1-nitropyrene and dinitropyrenes in the human hepatoma cell line HepG2. (Q35031055)

5 August 2017

title

Pathways for the mutagenesis of 1-nitropyrene and dinitropyrenes in the human hepatoma cell line HepG2. (English)

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5 August 2017

main subject

hepatocellular carcinoma

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K J Silvers

1

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5 August 2017

E P Eddy

2

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5 August 2017

E C McCoy

3

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5 August 2017

H S Rosenkranz

4

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5 August 2017

P C Howard

5

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5 August 2017

publication date

1 October 1994

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5 August 2017

number of pages

6

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Environmental Health Perspectives

inferred from page(s)

published in

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5 August 2017

volume

102 Suppl 6

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5 August 2017

page(s)

195-200

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Metabolism of 1-nitro[14C]pyrene in vivo in the rat and mutagenicity of urinary metabolites

5 August 2017

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Use of an established human hepatoma cell line with endogenous bioactivation for gene mutation studies

8 July 2018

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Mutagenicity of the phenolic microsomal metabolites of 3-nitrofluoranthene and 1-nitropyrene in strains of Salmonella typhimurium

8 July 2018

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Modulation of albumin secretion by ornithine alpha-ketoglutarate in adult rat hepatocyte cultures and a human hepatoma cell line (HepG2).

8 July 2018

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delta-Aminolaevulinate synthase in human HepG2 hepatoma cells. Repression by haemin and induction by chemicals

8 July 2018

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8 July 2018

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8 July 2018

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Salmonella typhimurium TA100Tn5-1012, a strain deficient in arylhydroxylamine O-esterificase, exhibits a reduced nitroreductase activity

8 July 2018

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DNA adduct formation in target tissues of Sprague-Dawley rats, CD-1 mice and A/J mice following tumorigenic doses of 1-nitropyrene.

8 July 2018

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The metabolism of 1-nitropyrene by human cytochromes P450.

8 July 2018

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Comparative carcinogenicities of 1-, 2-, and 4-nitropyrene and structurally related compounds in the female CD rat.

8 July 2018

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Kinetics and cofactor requirements for the nitroreductive metabolism of 1-nitropyrene and 3-nitrofluoranthene by rabbit liver aldehyde oxidase

8 July 2018

1 reference

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Species differences in metabolic activation and inactivation of 1-nitropyrene in the liver

8 July 2018

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Characterization of a bile salt-dependent cholesteryl ester hydrolase activity secreted from HepG2 cells

8 July 2018

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Cytochrome P-450 3A4 (nifedipine oxidase) is responsible for the C-oxidative metabolism of 1-nitropyrene in human liver microsomal samples

8 July 2018

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Subcellular localization of squalene synthase in human hepatoma cell line Hep G2

8 July 2018

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Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

8 July 2018

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Metabolic activation of benzo[a]pyrene by a human hepatoma cell line.

8 July 2018

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A cautionary note the use of nitroreductase-deficient strains of Salmonella typhimurium for the detection of nitroarenes as mutagens in complex mixtures including diesel exhausts

25 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566863

The basis of the insensitivity of Salmonella typhimurium strain TA98/1,8-DNP6 to the mutagenic action of nitroarenes

25 October 2018

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Formation of DNA adducts in vitro and in Salmonella typhimurium upon metabolic reduction of the environmental mutagen 1-nitropyrene

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566863

Comparison of the metabolic activation of 7, 12-dimethylbenz(a)anthracene by a human hepatoma cell line (HepG2) and low passage hamster embryo cells

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566863

Mutagenesis in Chinese hamster cells by cyclopenta(a)phenanthrenes activated by a human hepatoma cell line

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566863

1-Nitrosopyrene: an intermediate in the metabolic activation of 1-nitropyrene to a mutagen in Salmonella typhimurium TA1538.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566863

Effects of eicosapentaenoic and docosahexaenoic acids on apoprotein B mRNA and secretion of very low density lipoprotein in HepG2 cells

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566863

Effect of cell cholesterol content on apolipoprotein B secretion and LDL receptor activity in the human hepatoma cell line, HepG2.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1566863

Secretion of cholesteryl ester transfer protein-lipoprotein complexes by human HepG2 hepatocytes

25 October 2018

1 reference

12 December 2020

Characterization of the major apolipoproteins secreted by two human hepatoma cell lines

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12 December 2020

Xanthine oxidase catalyzed binding of 1-nitropyrene to DNA

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12 December 2020

Transformation of normal human skin fibroblasts by 1-nitropyrene and 6-nitrobenzo [a] pyrene

1 reference

12 December 2020

Evaluation of a human hepatoma cell line as a target cell in genetic toxicology

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12 December 2020

Mutagenic activity of methyl- and fluoro-substituted derivatives of polycyclic aromatic hydrocarbons in a human hepatoma (HepG2) cell-mediated assay

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12 December 2020

Heparin induces the expression of hepatic triglyceride lipase in a human hepatoma (HepG2) cell line

1 reference

12 December 2020

The kinetics of 1-nitropyrene and 3-nitrofluoranthene metabolism using bovine liver xanthine oxidase

1 reference

12 December 2020

An examination of the weak mutagenic response of 1-nitropyrene in Chinese hamster ovary cells

1 reference

12 December 2020

Cytotoxicity, cellular transformation and DNA adducts in normal human diploid fibroblasts exposed to 1-nitrosopyrene, a reduced derivative of the environmental contaminant, 1-nitropyrene

1 reference

12 December 2020

Identifiers

DOI

10.1289/EHP.94102S6195

1 reference

5 August 2017

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5 August 2017

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