The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications. (Q35031245)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12493535%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

review article

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title

The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications (English)

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16 December 2019

1

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16 December 2019

author name string

Aaron Janowsky

series ordinal

2

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16 December 2019

publication date

1 January 2003

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Pharmacology & Therapeutics

16 December 2019

published in

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16 December 2019

volume

97

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16 December 2019

issue

1

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16 December 2019

page(s)

55-85

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Perinatal changes in hypothalamic N-methyl-D-aspartate receptors and their relationship to gonadotropin-releasing hormone neurons.

16 December 2019

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7 January 2021

Cocaine treatment- and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Ethanol inhibits NMDA-activated ion current in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Localization of N-methyl-D-aspartate NR2B subunits on primary sensory neurons that give rise to small-caliber sciatic nerve fibers in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Declines in mRNA expression of different subunits may account for differential effects of aging on agonist and antagonist binding to the NMDA receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Loss of hippocampal [3H]TCP binding in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Increased hippocampal AMPA and NMDA receptor subunit immunoreactivity in temporal lobe epilepsy patients

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Chronic blockade of N-methyl-D-aspartate receptors alters gamma-aminobutyric acid type A receptor peptide expression and function in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

N-methyl-D-aspartic acid receptor structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Nitric oxide modulates synaptic vesicle docking fusion reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Changes in gene expression and neuronal phenotype in brain stem pain modulatory circuitry after inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Identification of subunits contributing to synaptic and extrasynaptic NMDA receptors in Golgi cells of the rat cerebellum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

On the nature and differential distribution of mRNAs in hippocampal neurites: implications for neuronal functioning

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Effects of neurosteroids on Ca(2+) signaling mediated by recombinant N-methyl-D-aspartate receptor expressed in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Laminar and cellular distribution of AMPA, kainate, and NMDA receptor subunits in monkey sensory-motor cortex.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Molecular evidence for the involvement of NR2B subunit containing N-methyl-D-aspartate receptors in the development of morphine-induced place preference.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Implications of the NR2B subunit-containing NMDA receptor localized in mouse limbic forebrain in ethanol dependence

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Antiparkinsonian actions of blockade of NR2B-containing NMDA receptors in the reserpine-treated rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

NMDAR-2A subunit protein expression is reduced in the hippocampus of rats exposed to Pb2+ during development.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

N-methyl-D-aspartate receptor subunit changes are associated with lead-induced deficits of long-term potentiation and spatial learning.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

NR2B selective NMDA receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Novel polymorphism in the gene region encoding the carboxyl-terminal intracellular domain of the NMDA receptor 2B subunit: analysis of association with schizophrenia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Enhanced tyrosine phosphorylation of striatal NMDA receptor subunits: effect of dopaminergic denervation and L-DOPA administration.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Effect of dopamine denervation and dopamine agonist administration on serine phosphorylation of striatal NMDA receptor subunits.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Modulation of NMDA receptor subunit mRNA in butorphanol-tolerant and -withdrawing rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Molecular determinants of NMDA receptor function in GABAergic neurones of rat forebrain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Stoichiometry of recombinant N-methyl-D-aspartate receptor channels inferred from single-channel current patterns

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Photic entrainment of circadian rhythms in rodents

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Ontogeny of ionotropic glutamate receptor expression in human fetal brain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Molecular determinants of NMDA receptor internalization

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

NMDA receptor and the tyrosine phosphorylation of its 2B subunit in taste learning in the rat insular cortex.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Coexpression of postsynaptic density-95 protein with NMDA receptors results in enhanced receptor expression together with a decreased sensitivity to L-glutamate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

The fyn art of N-methyl-D-aspartate receptor phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

A developmental change in NMDA receptor-associated proteins at hippocampal synapses

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Molecular mechanisms of calcium-dependent excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Transient expression of NMDA receptor subunit NR2B in the developing rat heart.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Changes in protein tyrosine phosphorylation in the rat brain after cerebral ischemia in a model of ischemic tolerance.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Antiparkinsonian actions of CP-101,606, an antagonist of NR2B subunit-containing N-methyl-d-aspartate receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl- D-aspartate receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Mechanism and Regulation of Calcium/Calmodulin-dependent Protein Kinase II Targeting to the NR2B Subunit of theN-Methyl-d-aspartate Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Association of calcium/calmodulin-dependent kinase II with developmentally regulated splice variants of the postsynaptic density protein densin-180.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Expression of NR1, NR2A-D, and NR3 subunits of the NMDA receptor in the cerebral cortex and olfactory bulb of adult rat

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

N-Methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Genetic enhancement of learning and memory in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Regulation of the expression of NR1 NMDA glutamate receptor subunits during hippocampal LTP

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Alterations in the expression of specific glutamate receptor subunits following hippocampal LTP in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Immunohistochemical localization of N-methyl-D-aspartate receptor NR1, NR2A, NR2B and NR2C/D subunits in the adult mammalian cerebellum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Fast NMDA receptor-mediated synaptic currents in neurons from mice lacking the epsilon2 (NR2B) subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Association analysis for the genetic variants of the NMDA receptor subunit 2b and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Dynamic interaction between soluble tubulin and C-terminal domains of N-methyl-D-aspartate receptor subunits.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Characterization of NMDA Receptor Subunit-Specific Antibodies: Distribution of NR2A and NR2B Receptor Subunits in Rat Brain and Ontogenic Profile in the Cerebellum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Effects of post-mortem delay on subunits of ionotropic glutamate receptors in human brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Differential effects of electroconvulsive shock on the glutamate receptor mRNAs for NR2A, NR2B and mGluR5b.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Genetic enhancement of inflammatory pain by forebrain NR2B overexpression

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Biphasic changes in the levels of N-methyl-D-aspartate receptor-2 subunits correlate with the induction and persistence of long-term potentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Nitric oxide increases calcium/calmodulin-dependent phosphorylation of proteins in the postsynaptic density of adult rat cerebral cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Determination of the N-methyl-D-aspartate receptor NR2B subunit blocker Ro 63-1908 in rat, cynomolgus monkey and human plasma by high-performance liquid chromatography with column switching and fluorescence detection.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Mutant huntingtin enhances excitotoxic cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Transient global ischemia alters NMDA receptor expression in rat hippocampus: correlation with decreased immunoreactive protein levels of the NR2A/2B subunits, and an altered NMDA receptor functionality.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Dynamic modulation of NMDA-induced responses by ifenprodil in rat prefrontal cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

Glutamate receptors and persistent pain: targeting forebrain NR2B subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900302-9

7 January 2021

10.1016/S0163-7258(02)00302-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12493535%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference