Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions (Q35033003)

5 August 2017

1 reference

title

Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions (English)

1 reference

5 August 2017

1 reference

1 reference

J A Johnson

1

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PubMed ID

21289619

5 August 2017

S B Liggett

series ordinal

2

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PubMed ID

21289619

5 August 2017

language of work or name

English

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publication date

2 February 2011

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Clinical Pharmacology & Therapeutics

5 August 2017

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5 August 2017

89

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5 August 2017

3

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5 August 2017

366-378

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Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes

5 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

HK-2 human renal proximal tubule cells as a model for G protein-coupled receptor kinase type 4-mediated dopamine 1 receptor uncoupling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Clinical and genetic modifiers of long-term survival in heart failure

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

beta-adrenergic receptor gene polymorphisms and beta-blocker treatment outcomes in hypertension

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Pharmacogenetics of beta-blockers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Pharmacology and physiology of human adrenergic receptor polymorphisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

The myocardium-protective Gly-49 variant of the beta 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

G protein-coupled receptor kinase 4 gene variants in human essential hypertension

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110683

β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

8 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Impact of beta1-adrenergic receptor polymorphisms on susceptibility to heart failure, arrhythmogenesis, prognosis, and response to beta-blocker therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Ser49Gly of beta1-adrenergic receptor is associated with effective beta-blocker dose in dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Common genetic variation of beta1- and beta2-adrenergic receptor and response to four classes of antihypertensive treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to beta-blocker therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Beta-adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2010.315

Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects

21 January 2018

1 reference

12 December 2020

Inotropic and sympathetic responses to the intracoronary infusion of a beta2-receptor agonist: a human in vivo study

1 reference

12 December 2020

Optimisation of antihypertensive treatment by crossover rotation of four major classes

1 reference

12 December 2020

Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure

1 reference

12 December 2020

beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and stroke

1 reference

12 December 2020

alpha 2A/alpha 2C-adrenergic receptor third loop chimera show that agonist interaction with receptor subtype backbone establishes G protein-coupled receptor kinase phosphorylation

1 reference

12 December 2020

Identifiers

DOI

10.1038/CLPT.2010.315

1 reference

release_nxtpgxkt4valvjywrrjap5q3oi

5 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nxtpgxkt4valvjywrrjap5q3oi

24 November 2022

mapped directly with Wikidata item

PMCID

3110683

1 reference

5 August 2017

1 reference

PubMed ID

21289619