Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors? (Q35033301)

5 August 2017

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title

Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors? (English)

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G protein-coupled receptor

5 August 2017

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5

Daniel Fourmy

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5 August 2017

Elodie Archer

1

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5 August 2017

Bernard Maigret

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2

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5 August 2017

Chantal Escrieut

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3

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5 August 2017

Lucien Pradayrol

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4

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5 August 2017

1 January 2003

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Trends in Pharmacological Sciences

5 August 2017

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5 August 2017

24

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5 August 2017

1

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5 August 2017

36-40

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Molecular tinkering of G protein-coupled receptors: an evolutionary success

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Drug discovery: a historical perspective

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Initial sequencing and analysis of the human genome

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The Sequence of the Human Genome

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Identification of G protein-coupled receptor genes from the human genome sequence

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Target validation of G-protein coupled receptors

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Orphan G-protein-coupled receptors and natural ligand discovery

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Crystal structure of rhodopsin: A G protein-coupled receptor

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Rational drug discovery revisited: interfacing experimental programs with bio- and chemo-informatics

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Three-dimensional model of purple membrane obtained by electron microscopy

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7 January 2021

Projection structure of frog rhodopsin in two crystal forms

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7 January 2021

Arrangement of rhodopsin transmembrane α-helices

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7 January 2021

The probable arrangement of the helices in G protein-coupled receptors.

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Visualisation and integration of G protein-coupled receptor related information help the modelling: description and applications of the Viseur program.

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Receptor activation: what does the rhodopsin structure tell us?

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7 January 2021

Activation of rhodopsin: new insights from structural and biochemical studies

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7 January 2021

Seven-transmembrane receptors: crystals clarify

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Multiple sequence alignment with hierarchical clustering

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Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin.

1 reference

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Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state

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7 January 2021

Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin.

1 reference

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Contrasting roles of leu(356) in the human CCK(1) receptor for antagonist SR 27897 and agonist SR 146131 binding

1 reference

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7 January 2021

Essential role of extracellular charged residues of the human CCK(1) receptor for interactions with SR 146131, SR 27897 and CCK-8S

1 reference

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7 January 2021

The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process

1 reference

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7 January 2021

Refinement of the conformation of a critical region of charge-charge interaction between cholecystokinin and its receptor

1 reference

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7 January 2021

Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy

1 reference

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7 January 2021

Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor

1 reference

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7 January 2021

Mutational analysis of the putative devazepide binding site of the CCKA receptor

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Minireview: Insights into G protein-coupled receptor function using molecular models

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7 January 2021

Control of conformational equilibria in the human B2 bradykinin receptor. Modeling of nonpeptidic ligand action and comparison to the rhodopsin structure.

1 reference

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Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor.

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Structure of rhodopsin and the superfamily of seven-helical receptors: the same and not the same

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7 January 2021

NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix

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NMR and modeling studies of a synthetic extracellular loop II of the kappa opioid receptor in a DPC micelle

1 reference

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7 January 2021

Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor

1 reference

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7 January 2021

10.1016/S0165-6147(02)00009-3

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DOI

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5 August 2017

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