Salivary (SD-type) cystatins: over one billion years in the making--but to what purpose? (Q35033473)

5 August 2017

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title

Salivary (SD-type) cystatins: over one billion years in the making--but to what purpose? (English)

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5 August 2017

Dickinson DP

1

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PubMed ID

12499242

5 August 2017

language of work or name

English

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publication date

1 January 2002

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Journal of Dental Research

5 August 2017

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5 August 2017

13

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5 August 2017

6

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5 August 2017

485-508

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Abnormally high levels of cystatin S in submandibular glands, saliva, and gingiva of plaque-resistant rats

5 August 2017

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Corn kernel cysteine proteinase inhibitor as a novel cystatin superfamily member of plant origin. Molecular cloning and expression studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

The human cystatin C gene (CST3), mutated in hereditary cystatin C amyloid angiopathy, is located on chromosome 20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Structure and expression of the human cystatin C gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Human cystatin C. role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Modification of cystatin C activity by bacterial proteinases and neutrophil elastase in periodontitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

A cysteine protease inhibitor stored in the large granules of horseshoe crab hemocytes: purification, characterization, cDNA cloning and tissue localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Antiviral effect of oryzacystatin, a proteinase inhibitor in rice, against herpes simplex virus type 1 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Hairpin loop mutations of chicken cystatin have different effects on the inhibition of cathepsin B, cathepsin L and papain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Expressions of the genes for cysteine proteinase inhibitors cystatin C and cystatin S in rat submandibular salivary gland.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cystatins in human tear fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cysteine protease inhibitory activity and levels of salivary cystatins in whole saliva of periodontally diseased patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

The effect of adrenergic agonists and antagonists on cysteine-proteinase inhibitor (cystatin) in rat saliva

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Production of rat salivary cystatin S variant polypeptides in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Examination of the potential structure of human salivary cystatins based on computer modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Proteinase inhibition, immunoglobulin-binding proteins and a novel antimicrobial principle

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

The importance of the second hairpin loop of cystatin C for proteinase binding. Characterization of the interaction of Trp-106 variants of the inhibitor with cysteine proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cystatins--inhibitors of cysteine proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Purification and characterization of a new cystatin inhibitor from Taiwan cobra (Naja naja atra) venom

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Fetuin--an old friend revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cruzipain, the major cysteine proteinase from the protozoan parasite Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Induction of type 2 cystatin in rat submandibular glands by systemically administered agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

The cDNA structure and expression analysis of the genes for the cysteine proteinase inhibitor cystatin C and for beta 2-microglobulin in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Inhibitory effects of recombinant human cystatin C on human coronaviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Structure, alternative splicing and chromosomal localization of the cystatin-related epididymal spermatogenic gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cystatin C and cathepsin B in human colon carcinoma: expression by cell lines and matrix degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Structure, organization and regulation of a rat cysteine proteinase inhibitor-encoding gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Elevation of cystatin C in susceptible neurons in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Salivary glands: a paradigm for diversity of gland development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

The structures of native phosphorylated chicken cystatin and of a recombinant unphosphorylated variant in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Isolation of the human testatin gene and analysis in patients with abnormal gonadal development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Identification of salivary proteins inhibiting herpes simplex virus 1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Mouse and rat cystatin C: Escherichia coli production, characterization and tissue distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Leukocystatin, a new Class II cystatin expressed selectively by hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Importance of the evolutionarily conserved glycine residue in the N-terminal region of human cystatin C (Gly-11) for cysteine endopeptidase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Structural basis for the biological specificity of cystatin C. Identification of leucine 9 in the N-terminal binding region as a selectivity-conferring residue in the inhibition of mammalian cysteine peptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

A filarial cysteine protease inhibitor down-regulates T cell proliferation and enhances interleukin-10 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Protein composition of whole and parotid saliva in healthy and periodontitis subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Effect of periodontal treatment on the protein composition of whole and parotid saliva

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Isolation and molecular cloning of a novel bone phosphoprotein related in sequence to the cystatin family of thiol protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Molecular cloning, expression and modelling of cat allergen, cystatin (Fel d 3), a cysteine protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Characterization and amino acid sequence of a new acidic cysteine proteinase inhibitor (cystatin SA) structurally closely related to cystatin S, from human whole saliva

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Identification of Full-Sized Forms of Salivary (Type) Cystatins (Cystatin SN, Cystatin SA, Cystatin S, and Two Phosphorylated Forms of Cystatin S) in Human Whole Saliva and Determination of Phosphorylation Sites of Cystatin S

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

New types of clotting factors and defense molecules found in horseshoe crab hemolymph: their structures and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cloning and targeted deletion of the mouse fetuin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Walking, cloning, and mapping with YACs in 3q27: localization of five ESTs including three members of the cystatin gene family and identification of CpG islands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

A plant defensive cystatin (soyacystatin) targets cathepsin L-like digestive cysteine proteinases (DvCALs) in the larval midgut of western corn rootworm (Diabrotica virgifera virgifera).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Salivary cystatin SA-III, a potential precursor of the acquired enamel pellicle, is phosphorylated at both its amino- and carboxyl-terminal regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Neutrophil chemotactic activity is modulated by human cystatin C, an inhibitor of cysteine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Modulation of phagocytosis-associated respiratory burst by human cystatin C: role of the N-terminal tetrapeptide Lys-Pro-Pro-Arg

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Salivary cystatin activity and cystatin C in natural and experimental gingivitis in smokers and non-smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cystatin C deficiency is associated with the progression of small abdominal aortic aneurysms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Immune evasion genes from filarial nematodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Amino acid substitutions in the N-terminal segment of cystatin C create selective protein inhibitors of lysosomal cysteine proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Up-regulation of cystatin C by microglia in the rat facial nucleus following axotomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Immunocytochemical study of cathepsin L and rat salivary cystatin-3 in rat osteoclasts treated with E-64 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Bactericidal effect of rat cystatin S on an oral bacterium Porphyromonas gingivalis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Glossopharyngeal denervation alters responses to nutrients and toxic substances

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Postnatal changes of gene expression for tissue inhibitors of metalloproteinase-1 and -2 and cystatins S and C, in rat submandibular gland demonstrated by quantitative reverse transcription-polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Isolation of three forms of cystatin from submandibular saliva of isoproterenol-treated rats, its properties and kinetic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cystatin C, a protease inhibitor, in degenerating rat hippocampal neurons following transient forebrain ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration By release of loop anchoring through mutation of his110.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Evolution of proteins of the cystatin superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cathepsins and compartmentalization in antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Longitudinal study of relations between human salivary antimicrobial proteins and measures of dental plaque accumulation and composition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Interactions of human lacrimal and salivary cystatins with adenovirus endopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Tissue distribution of RNAs for cystatins, histatins, statherin, and proline-rich salivary proteins in humans and macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

The serum protein alpha2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells. A possible role in mineralization and calcium homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Human histidine-rich glycoprotein expressed in SF9 insect cells inhibits apatite formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Expression and induction by beta-adrenergic agonists of the cystatin S gene in submandibular glands of developing rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cystatin C deficiency in human atherosclerosis and aortic aneurysms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Transforming growth factor beta regulates cystatin C in serum-free mouse embryo (SFME) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Assignment of a novel cysteine proteinase inhibitor (CST6) to 11q13 by fluorescence in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Growth stimulation of 3T3 fibroblasts by cystatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Assignment of secreted phosphoprotein 24 (SPP2) to human chromosome band 2q37-->qter by in situ hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Differential effect toward inhibition of papain and cathepsin C by recombinant human salivary cystatin SN and its variants produced by a baculovirus system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

The cystatins: Protein inhibitors of cysteine proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

BJ46a, a snake venom metalloproteinase inhibitor. Isolation, characterization, cloning and insights into its mechanism of action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

The salivary lipocalin von Ebner's gland protein is a cysteine proteinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Constitutive secretion of cystatin C (gamma-trace) by monocytes and macrophages and its downregulation after stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Tissue-specific expression and androgen regulation of different genes encoding rat prostatic 22-kilodalton glycoproteins homologous to human and rat cystatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Induction of a specific (LM) protein in the submandibular gland of the rat by repeated amputation of the lower incisor teeth

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Molecular cloning and gene expression of chum salmon cystatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Comparison in localization between cystatin C and cathepsin K in osteoclasts and other cells in mouse tibia epiphysis by immunolight and immunoelectron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

MHC class II molecules, cathepsins, and La/SSB proteins in lacrimal acinar cell endomembranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

The cathelicidin family of antimicrobial peptide precursors: a component of the oxygen-independent defense mechanisms of neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F154411130201300606

10.1177/154411130201300606

21 January 2018

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12499242