A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit. (Q35037268)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11259679%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit (English)

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5 November 2019

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2

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5 November 2019

author name string

L Belova

1

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5 November 2019

L Xiong

3

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5 November 2019

P M McNicholas

4

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5 November 2019

A S Mankin

5

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5 November 2019

language of work or name

English

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publication date

20 March 2001

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Proceedings of the National Academy of Sciences of the United States of America

5 November 2019

published in

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5 November 2019

volume

98

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5 November 2019

issue

7

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5 November 2019

page(s)

3726-3731

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Presence of variations in ribosomal protein L16 corresponding to susceptibility of enterococci to oligosaccharides (Avilamycin and evernimicin).

5 November 2019

cites work

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Evernimicin (SCH27899) inhibits a novel ribosome target site: analysis of 23S ribosomal DNA mutants.

8 July 2018

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8 July 2018

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Evernimicin (SCH27899) inhibits both translation and 50S ribosomal subunit formation in Staphylococcus aureus cells

8 July 2018

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Evernimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both gram-positive and gram-negative bacteria

8 July 2018

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Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action.

8 July 2018

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Identification of 50S components neighboring 23S rRNA nucleotides A2448 and U2604 within the peptidyl transferase center of Escherichia coli ribosomes

8 July 2018

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Recognition of the codon-anticodon helix by ribosomal RNA.

8 July 2018

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Pactamycin resistance mutations in functional sites of 16 S rRNA.

8 July 2018

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8 July 2018

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8 July 2018

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Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Further characterization of particulate fractions from lysed cell envelopes of Halobacterium halobium and isolation of gas vacuole membranes

8 July 2018

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23S ribosomal RNA mutations in halobacteria conferring resistance to the anti-80S ribosome targeted antibiotic anisomycin

8 July 2018

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Intermediate states in the movement of transfer RNA in the ribosome

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Functional interactions within 23S rRNA involving the peptidyltransferase center.

8 July 2018

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8 July 2018

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Identification of a ribosomal protein essential for peptidyl transferase activity

8 July 2018

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8 July 2018

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8 July 2018

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Antimicrobial activity and spectrum of SCH27899 (Ziracin) tested against gram-positive species including recommendations for routine susceptibility testing methods and quality control. Quality Control Study Group.

21 January 2018

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Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mutations in the peptidyl transferase center of 23 S rRNA reveal the site of action of sparsomycin, a universal inhibitor of translation

21 January 2018

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Catalysis of peptide bond formation by 50 s ribosomal subunits from Escherichia coli

21 January 2018

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21 January 2018

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The peptidyltransferase centre of the Escherichia coli ribosome. The histidine of protein L16 affects the reconstitution and control of the active centre but is not essential for release-factor-mediated peptidyl-tRNA hydrolysis and peptide bond forma

21 January 2018

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Ribosomal components neighboring the 2475 loop in Escherichia coli 50S subunits

21 January 2018

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Binding of Escherichia coli initiation factor IF2 to 30S ribosomal subunits: a functional role for the N-terminus of the factor

21 January 2018

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Topography of the Escherichia coli ribosomal 30S subunit-initiation factor 2 complex

21 January 2018

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Cross-linking of initiation factor IF2 to proteins L7/L12 in 70 S ribosomes of Escherichia coli

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11259679

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification by photoaffinity labelling of 16S RNA as a component of IF2-binding site of E. coli MRE 600 ribosome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11259679

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11259679

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.071527498

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11259679%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11259679%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference