Normal brain ageing: models and mechanisms (Q35038212)

5 August 2017

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title

Normal brain ageing: models and mechanisms (English)

1 reference

5 August 2017

Emil C Toescu

1

1 reference

PubMed ID

16321805

5 August 2017

language of work or name

English

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publication date

1 December 2005

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5 August 2017

8

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Philosophical Transactions of the Royal Society B

inferred from page(s)

published in

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5 August 2017

360

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5 August 2017

1464

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5 August 2017

2347-2354

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Ca2+ regulation and gene expression in normal brain aging

5 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

The aging brain: morphomolecular senescence of cortical circuits

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Reduced mitochondrial buffering of voltage-gated calcium influx in aged rat basal forebrain neurons.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Mitochondrial membrane potential and aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

The role of mitochondrial oxidative stress in aging.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Impact of aging on hippocampal function: plasticity, network dynamics, and cognition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Megamitochondria formation - physiology and pathology.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Demography. Broken limits to life expectancy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Time to talk SENS: critiquing the immutability of human aging.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

An energy budget for signaling in the grey matter of the brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Does oxidative damage to DNA increase with age?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Parameters of calcium homeostasis in normal neuronal ageing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Mitochondrial calcium transport: mechanisms and functions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Allostasis, allostatic load, and the aging nervous system: role of excitatory amino acids and excitotoxicity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Mitochondria and neuronal survival

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

N-methyl-D-aspartate excitotoxicity: relationships among plasma membrane potential, Na(+)/Ca(2+) exchange, mitochondrial Ca(2+) overload, and cytoplasmic concentrations of Ca(2+), H(+), and K(+).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Neuronal cell death: a demise with different shapes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Biodemographic trajectories of longevity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

The role of intracellular Na+ and mitochondria in buffering of kainate-induced intracellular free Ca2+ changes in rat forebrain neurones.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Life and death of neurons in the aging brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Morphological alterations of synaptic mitochondria during aging. The effect of Hydergine treatment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Transport of calcium by mitochondria

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Calcium hypothesis of Alzheimer's disease and brain aging.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

A hierarchy of ATP-consuming processes in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Mitochondrial role in cell aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

The effect of age on outcome following traumatic brain injury in rats

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

An update on the mitochondrial-DNA mutation hypothesis of cell aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Protein oxidation and aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

8 July 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Biological evidence for limits to the duration of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

The mitochondrial calcium uniporter is a highly selective ion channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Age-dependent effects of glutamate toxicity in the hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Maturation of vulnerability to excitotoxicity: intracellular mechanisms in cultured postnatal hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Which synapses are affected in aging and what is the nature of their vulnerability? A commentary on "life span and synapses: will there be a primary senile dementia?".

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Life span and synapses: will there be a primary senile dementia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Calcium and neuronal ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Mitochondrial polarisation status and [Ca2+]i signalling in rat cerebellar granule neurones aged in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1771

Roman conquest, lifespan, and diseases in ancient Italy

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Changes in mitochondrial status associated with altered Ca2+ homeostasis in aged cerebellar granule neurons in brain slices.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Traumatic brain injury in the elderly: increased mortality and worse functional outcome at discharge despite lower injury severity.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569594

Free radical theory of aging: dietary implications

25 October 2018

1 reference

12 December 2020

1 reference

12 December 2020

Mitochondria and Ca(2+) signaling

1 reference

12 December 2020

Metabolic substrates of neuronal aging

1 reference

12 December 2020

Glutamate-induced neuron death requires mitochondrial calcium uptake

1 reference

12 December 2020

Conditions influencing yield and analysis of 8-hydroxy-2'-deoxyguanosine in oxidatively damaged DNA

1 reference

12 December 2020

Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

1 reference

12 December 2020

Identifiers

DOI

10.1098/RSTB.2005.1771

1 reference

5 August 2017

1 reference

5 August 2017

1 reference

PubMed ID

16321805