Clinical development of mammalian target of rapamycin inhibitors (Q35038759)

5 August 2017

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title

Clinical development of mammalian target of rapamycin inhibitors (English)

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5 August 2017

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Janet E Dancey

1

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5 August 2017

1 October 2002

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Hematology / Oncology Clinics of North America

5 August 2017

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5 August 2017

16

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5 August 2017

5

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5 August 2017

1101-1114

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Molecular mechanisms for the control of translation by insulin

5 August 2017

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2.

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling.

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

The TOR kinases link nutrient sensing to cell growth

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

TOR, a central controller of cell growth

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

PI3-kinase inhibition: a target for drug development?

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

The mRNA 5' cap-binding protein eIF4E and control of cell growth

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

mTOR inhibitors: an overview

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

New antitumor substances of natural origin

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Activity of rapamycin (AY-22,989) against transplanted tumors

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Studies on the mechanism of resistance to rapamycin in human cancer cells

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

The tyrosine89 residue of yeast FKBP12 is required for rapamycin binding

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Principles of CDK regulation

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Inhibitors of mammalian G1 cyclin-dependent kinases

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Pharmacokinetics and tolerability of 40-0-[2-hydroxyethyl]rapamycin in de novo liver transplant recipients

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Rapamycin may prevent post-transplant lymphoma

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Is òne cycle every three or four weeks' obsolete? A critical review of dose-dense chemotherapy in solid neoplasms

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Interstitial pneumonitis associated with sirolimus (rapamycin) therapy after liver transplantation

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https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Provocative effects of the immunosuppressants rapamycin, tacrolimus, and dexamethasone on pneumonitis in contrast to the anti- pneumonitis effects of mycophenolate mofetil

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Cell cycle progression and proliferation despite 4BP-1 dephosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development?

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

1 reference

https://api.crossref.org/works/10.1016%2FS0889-8588%2802%2900051-5

7 January 2021

10.1016/S0889-8588(02)00051-5

Identifiers

DOI

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5 August 2017

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PubMed ID

12512385