BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist (Q35042022)

6 August 2017

title

BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist (English)

1 reference

6 August 2017

9

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author name string

Y Dumont

1

1 reference

6 August 2017

A Cadieux

2

1 reference

6 August 2017

H Doods

3

1 reference

6 August 2017

L H Pheng

4

1 reference

6 August 2017

R Abounader

5

1 reference

6 August 2017

E Hamel

6

1 reference

6 August 2017

D Jacques

7

1 reference

6 August 2017

D Regoli

8

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 March 2000

1 reference

British Journal of Pharmacology

6 August 2017

published in

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6 August 2017

volume

129

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6 August 2017

issue

6

1 reference

6 August 2017

page(s)

1075-1088

1 reference

[(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors

6 August 2017

cites work

1 reference

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BIIE0246: a selective and high affinity neuropeptide Y Y(2) receptor antagonist

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8 July 2018

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Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor

8 July 2018

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Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents

8 July 2018

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NPY-induced feeding involves the action of a Y1-like receptor in rodents

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8 July 2018

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GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists.

8 July 2018

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8 July 2018

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XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors

8 July 2018

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The neuropeptide Y Y1 antagonist, 1229U91, a potent agonist for the human pancreatic polypeptide-preferring (NPY Y4) receptor

8 July 2018

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Y-receptor subtypes--how many more?

8 July 2018

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The neuropeptide Y (NPY) Y1 receptor antagonist BIBP 3226: equal effects on vascular responses to exogenous and endogenous NPY in the pig in vivo

8 July 2018

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Characterization of Y3 receptor-mediated synaptic inhibition by chimeric neuropeptide Y-peptide YY peptides in the rat brainstem

8 July 2018

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The neuropeptide Y Y1 receptor selective radioligand, [125I][Leu31,Pro34]peptide YY, is also a high affinity radioligand for human pancreatic polypeptide 1 receptors

8 July 2018

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Multiple NPY receptors coexist in pre- and postsynaptic sites: inhibition of GABA release in isolated self-innervating SCN neurons.

8 July 2018

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Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue

8 July 2018

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Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species

8 July 2018

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Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide

8 July 2018

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Recent developments with neuropeptide Y receptor antagonists

8 July 2018

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Selective inhibition of neuropeptide Y Y1 receptors by BIBP3226 in rat and human epithelial preparations

8 July 2018

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BIBP 3226, the first selective neuropeptide Y1 receptor antagonist: a review of its pharmacological properties

8 July 2018

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Expression of the neuropeptide Y Y1 receptor in human embryonic kidney 293 cells: ligand binding characteristics, in situ hybridization and receptor autoradiography

8 July 2018

1 reference

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Receptor binding profiles of NPY analogues and fragments in different tissues and cell lines

8 July 2018

1 reference

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A receptor subtype involved in neuropeptide-Y-induced food intake

8 July 2018

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Inhibition of sympathetic vasoconstriction in pigs in vivo by the neuropeptide Y-Y1 receptor antagonist BIBP 3226.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Expression cloning of a human brain neuropeptide Y Y2 receptor

8 July 2018

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Neurobiology and clinical aspects of neuropeptide Y.

8 July 2018

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Characterization of neuropeptide Y (NPY) receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226.

8 July 2018

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Neuropeptide Y-related peptides and their receptors--are the receptors potential therapeutic drug targets?

8 July 2018

1 reference

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The rabbit saphenous vein: a tissue preparation specifically enriched in NPY-Y1 receptor subtype.

8 July 2018

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SR 120819A, an orally-active and selective neuropeptide Y Y1 receptor antagonist

8 July 2018

1 reference

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Novel modified carboxy terminal fragments of neuropeptide Y with high affinity for Y2-type receptors and potent functional antagonism at a Y1-type receptor

8 July 2018

1 reference

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The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Apparent affinity and potency of BIBP3226, a non-peptide neuropeptide Y receptor antagonist, on purported neuropeptide Y Y1, Y2 and Y3 receptors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Expression Cloning and Pharmacological Characterization of a Human Hippocampal Neuropeptide Y/Peptide YY Y2 Receptor Subtype

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

High-affinity neuropeptide Y receptor antagonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP 3226.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Effects of neuropeptide Y on the electrical properties of neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Modulation of memory processing by neuropeptide Y.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Evidence for different pre-and post-junctional receptors for neuropeptide Y and related peptides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Interaction of peptide YY with rat intestinal epithelial plasma membranes: binding of the radioiodinated peptide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Human brain receptor autoradiography using whole hemisphere sections: a general method that minimizes tissue artefacts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Peptide-YY and neuropeptide-Y inhibit vasoactive intestinal peptide-stimulated adenosine 3',5'-monophosphate production in rat small intestine: structural requirements of peptides for interacting with peptide-YY-preferring receptors

8 July 2018

1 reference

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Structural study of the N-terminal segment of neuropeptide tyrosine

8 July 2018

1 reference

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Cardiorespiratory response patterns elicited by microinjections of neuropeptide Y in the nucleus tractus solitarius

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Modulation of synaptic transmission in hippocampus by neuropeptide Y: presynaptic actions.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Comparative structural requirements of brain neuropeptide Y binding sites and vas deferens neuropeptide Y receptors

8 July 2018

1 reference

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[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist

8 July 2018

1 reference

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In vivo structure activity study supports the existence of heterogeneous neuropeptide Y receptors.

8 July 2018

1 reference

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Neurobehavioral profile of neuropeptide Y.

8 July 2018

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Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem

8 July 2018

1 reference

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Neuropeptide Y: a novel neuroendocrine peptide in the control of pituitary hormone secretion, and its relation to luteinizing hormone

8 July 2018

1 reference

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Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues

8 July 2018

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571943

Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects

8 July 2018

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Crossref

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Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor.

21 January 2018

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Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains

25 October 2018

1 reference

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Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain.

25 October 2018

1 reference

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Distribution of a novel hypothalamic neuropeptide Y receptor gene and it's absence in rat.

25 October 2018

1 reference

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Inhibition of synaptic transmission by neuropeptide Y in rat hippocampal area CA1: modulation of presynaptic Ca2+ entry.

25 October 2018

1 reference

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Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro.

25 October 2018

1 reference

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Characterization of neuropeptide Y receptor subtypes in the normal human brain, including the hypothalamus.

25 October 2018

1 reference

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Autoradiographic distribution of [125I]Leu31,Pro34]PYY and [125I]PYY3-36 binding sites in the rat brain evaluated with two newly developed Y1 and Y2 receptor radioligands.

25 October 2018

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On the sites of presynaptic inhibition by neuropeptide Y in rat hippocampus in vitro

25 October 2018

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Subpicomolar amounts of NPY(13-36) injected into the nucleus tractus solitarius of the rat counteract the cardiovascular responses to L-glutamate.

25 October 2018

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Nonpeptide peptidomimetic antagonists of the neuropeptide Y receptor: benextramine analogs with selectivity for the peripheral Y2 receptor

25 October 2018

1 reference

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Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus.

25 October 2018

1 reference

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The effect of neuropeptide Y on drinking in mice

25 October 2018

1 reference

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Non-adrenergic, non-cholinergic vascular control with reference to neuropeptide Y, vasoactive intestinal polypeptide and nitric oxide

25 October 2018

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12 December 2020

Neuropeptide Y2 receptors inhibit the frequency of spontaneous but not miniature EPSCs in CA3 pyramidal cells of rat hippocampus

1 reference

12 December 2020

Structure-activity relationship of novel pentapeptide neuropeptide Y receptor antagonists is consistent with a noncontinuous epitope for ligand-receptor binding

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12 December 2020

Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors

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12 December 2020

Neuropeptide Y Y1 receptors are involved in the vasoconstriction caused by human sympathetic nerve stimulation

1 reference

12 December 2020

Potent and selective 1,2,3-trisubstituted indole NPY Y-1 antagonists

1 reference

12 December 2020

GW1229, a novel neuropeptide Y Y1 receptor antagonist, inhibits the vasoconstrictor effect on neuropeptide Y in the hamster microcirculation

1 reference

12 December 2020

Characterization of neuropeptide Y binding sites in rat brain membrane preparations using [125I][Leu31,Pro34]peptide YY and [125I]peptide YY3-36 as selective Y1 and Y2 radioligands

1 reference

12 December 2020

Neuropeptide Y potentiates noradrenaline-induced contraction through the neuropeptide Y Y1 receptor

1 reference

12 December 2020

Signal epitopes in the three-dimensional structure of neuropeptide Y. Interaction with Y1, Y2, and pancreatic polypeptide receptors

1 reference

12 December 2020

Norepinephrine-like effects of neuropeptide Y on LH release in the rat

1 reference

12 December 2020

Stress-induced mesenteric vasoconstriction in rats is mediated by neuropeptide Y Y1 receptors

1 reference

12 December 2020

Identification and functional studies of a specific peptide YY-preferring receptor in dog adipocytes

1 reference

12 December 2020

Neuropeptide Y phase shifts the circadian clock in vitro via a Y2 receptor

1 reference

12 December 2020

The dog saphenous vein: a sensitive and selective preparation for the Y2 receptor of neuropeptide Y

1 reference

12 December 2020

Characterization of a selective antagonist of neuropeptide Y at the Y2 receptor. Synthesis and pharmacological evaluation of a Y2 antagonist

1 reference

12 December 2020

Peptide YY derivatives as selective neuropeptide Y/peptide YY Y1 and Y2 agonists devoided of activity for the Y3 receptor sub-type

1 reference

12 December 2020

Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5)

1 reference

12 December 2020

Peptide YY and neuropeptide Y in the gut: availability, biological actions, and receptors

1 reference

12 December 2020

Presence of neuropeptide Y Y1 receptor mediating vasoconstriction in human cerebral arteries

1 reference

12 December 2020

Neuropeptide Y phase shifts circadian rhythms in vivo via a Y2 receptor

1 reference

12 December 2020

Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide-preferring receptor

1 reference

12 December 2020

Characterization of neuropeptide Y receptors mediating contraction, potentiation and inhibition of relaxation

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0703162

1 reference

6 August 2017

1 reference

6 August 2017

1 reference