The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes. (Q35042474)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10903976%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

title

The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes (English)

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8 November 2019

1

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8 November 2019

author name string

L Cambridge

2

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8 November 2019

L A Hart

3

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8 November 2019

D A Stevens

4

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8 November 2019

M A Lindsay

5

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8 November 2019

P J Barnes

6

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8 November 2019

language of work or name

English

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publication date

1 July 2000

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8 November 2019

number of pages

9

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British Journal of Pharmacology

inferred from page(s)

published in

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8 November 2019

volume

130

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8 November 2019

issue

6

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8 November 2019

page(s)

1353-1361

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Therapeutic strategies for allergic diseases

8 November 2019

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1 reference

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8 July 2018

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Cloning and characterization of novel mouse and human secretory phospholipase A(2)s

8 July 2018

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Cox-2-selective inhibitors: the new super aspirins

8 July 2018

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Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2

8 July 2018

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A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2

8 July 2018

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

8 July 2018

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The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2

8 July 2018

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Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity.

8 July 2018

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Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation

8 July 2018

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Signaling through scaffold, anchoring, and adaptor proteins

8 July 2018

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Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta

8 July 2018

1 reference

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Function and inhibition of intracellular calcium-independent phospholipase A2.

8 July 2018

1 reference

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p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta

8 July 2018

1 reference

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The growing phospholipase A2 superfamily of signal transduction enzymes

8 July 2018

1 reference

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Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells

8 July 2018

1 reference

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p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2

8 July 2018

1 reference

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Sounding the alarm: protein kinase cascades activated by stress and inflammation

8 July 2018

1 reference

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Lipocortin 1 and the control of cPLA2 activity in A549 cells. Glucocorticoids block EGF stimulation of cPLA2 phosphorylation

8 July 2018

1 reference

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Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages.

8 July 2018

1 reference

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Maximal epidermal growth-factor-induced cytosolic phospholipase A2 activation in vivo requires phosphorylation followed by an increased intracellular calcium concentration.

8 July 2018

1 reference

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Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572191

cPLA2 is phosphorylated and activated by MAP kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572191

Differential role of extra- and intracellular calcium in bradykinin and interleukin 1 alpha stimulation of arachidonic acid release from A549 cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572191

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

8 July 2018

1 reference

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Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

8 July 2018

1 reference

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Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone

8 July 2018

1 reference

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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

8 July 2018

1 reference

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

8 July 2018

1 reference

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Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element

8 July 2018

1 reference

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

8 July 2018

1 reference

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Cyclooxygenase-2: regulation and relevance in inflammation

8 July 2018

1 reference

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v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor

8 July 2018

1 reference

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572191

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572191

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572191

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572191

Cloning and expression of cystolic phospholipase A2 (cPLA2) and a naturally occurring variant. Phosphorylation of Ser505 of recombinant cPLA2 by p42 mitogen-activated protein kinase results in an increase in specific activity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572191

Phospholipase A2 in alveolar type II epithelial cells: biochemical and immunologic characterization.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572191

Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572191

Activation of cytosolic phospholipase A2 by basic fibroblast growth factor via a p42 mitogen-activated protein kinase-dependent phosphorylation pathway in endothelial cells

25 October 2018

1 reference

12 December 2020

Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum

1 reference

12 December 2020

Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase

1 reference

12 December 2020

Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059

1 reference

12 December 2020

Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes.

1 reference

12 December 2020

Repression of Cyclooxygenase-2 and Prostaglandin E2Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA

1 reference

12 December 2020

p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes

1 reference

12 December 2020

Inducible cyclooxygenase may have anti-inflammatory properties

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12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0703431

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10903976%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10903976%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

1 reference