Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier (Q35046193)

6 August 2017

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title

Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier (English)

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6 August 2017

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Michel Demeule

1

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6 August 2017

Anthony Régina

2

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6 August 2017

Julie Jodoin

3

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6 August 2017

Alain Laplante

4

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6 August 2017

Claude Dagenais

5

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6 August 2017

France Berthelet

6

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6 August 2017

Albert Moghrabi

7

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6 August 2017

Richard Béliveau

8

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6 August 2017

1 June 2002

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6 August 2017

Vascular Pharmacology

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6 August 2017

38

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6 August 2017

339-348

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6 August 2017

6

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Transporting therapeutics across the blood-brain barrier

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

The multidrug-resistance gene MDR1 is expressed in human glial tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Ultrastructural and morphometric investigation of human brain capillaries in normal and peritumoral tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

ABC transporters in lipid transport

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

A family of drug transporters: the multidrug resistance-associated proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Structure and expression of the human MDR (P-glycoprotein) gene family

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Isolation of endothelial cells from brain, lung, and kidney: expression of the multidrug resistance P-glycoprotein isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Expression of multidrug-resistance P-glycoprotein (MDR1) in human brain tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

The biochemistry of P-glycoprotein-mediated multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Expression of a multidrug-resistance gene in human tumors and tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro

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https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

P-Glycoprotein on astrocyte foot processes of unfixed isolated human brain capillaries.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Determinants of passive drug entry into the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

P-glycoprotein expression in brain tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Regulation of volume-activated chloride channels by P-glycoprotein: phosphorylation has the final say!

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

High levels of P-glycoprotein detected in isolated brain capillaries.

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https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Interaction of drugs with P-glycoprotein in brain capillaries

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

A role for P-glycoprotein in regulating cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1).

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

beta-Amyloid efflux mediated by p-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Multidrug resistance in glioblastoma. Chemosensitivity testing and immunohistochemical demonstration of P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Reduced permeability in CHO cells as a mechanism of resistance to colchicine.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Blood-brain barrier biology and methodology

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Clinical trials of agents that reverse multidrug resistance. A literature review

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Effects of curcumin on P-glycoprotein in primary cultures of rat hepatocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Phosphatidylcholine translocase: a physiological role for the mdr2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Expression of the multidrug-resistance P-glycoprotein (Pgp, MDR-1) by endothelial cells of the neovasculature in central nervous system tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Immunohistochemical study of tight junction-related protein in neovasculature in astrocytic tumor.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

P-Glycoprotein, a gatekeeper in the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Structure-activity relationship of P-glycoprotein substrates and modifiers.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Multidrug-resistance transporters

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https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Cellular localization of P-glycoprotein in brain versus gonadal capillaries

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Carrier-mediated or specialized transport of drugs across the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Cyclosporins as drug resistance modifiers

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Characterization of a cytosolic heat-shock protein-caveolin chaperone complex. Involvement in cholesterol trafficking

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

The functional role of P-glycoprotein in the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Cortisol is transported by the multidrug resistance gene product P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Cholesterol interaction with the daunorubicin binding site of P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Brain bilirubin content is increased in P-glycoprotein-deficient transgenic null mutant mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Caveolin is an activator of insulin receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2802%2900201-X

7 January 2021

10.1016/S1537-1891(02)00201-X

Identifiers

DOI

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6 August 2017

1 reference