The transmissible spongiform encephalopathies: pathogenic mechanisms and strategies for therapeutic intervention (Q35050425)

6 August 2017

title

The transmissible spongiform encephalopathies: pathogenic mechanisms and strategies for therapeutic intervention (English)

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6 August 2017

Neil A Mabbott

3

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Mark W Head

object named as

Mark W Head

series ordinal

1

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author name string

Christine F Farquhar

series ordinal

2

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6 August 2017

Janet R Fraser

series ordinal

4

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6 August 2017

language of work or name

English

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publication date

1 October 2001

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Expert Opinion on Therapeutic Targets

6 August 2017

published in

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6 August 2017

volume

5

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6 August 2017

issue

5

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6 August 2017

page(s)

569-585

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Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Laboratory diagnosis of variant Creutzfeldt-Jakob disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Incidence of variant Creutzfeldt-Jakob disease in the UK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Signal transduction through prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

No propagation of prions in mice devoid of PrP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Assays of protease-resistant prion protein and its formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Chaperone-supervised conversion of prion protein to its protease-resistant form

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Aggregation and fibrillization of the recombinant human prion protein huPrP90-231.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Scrapie strains maintain biological phenotypes on propagation in a cell line in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Antioxidant activity related to copper binding of native prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Cellular prion protein binds laminin and mediates neuritogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Neurotoxicity of a prion protein fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

A neurotoxic and gliotrophic fragment of the prion protein increases plasma membrane microviscosity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Apoptosis-mediated neurotoxicity induced by beta-amyloid and PrP fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Activation of microglial cells by PrP and beta-amyloid fragments raises intracellular calcium through L-type voltage sensitive calcium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Role of microglia and host prion protein in neurotoxicity of a prion protein fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Intracellular calcium rise through L-type calcium channels, as molecular mechanism for prion protein fragment 106-126-induced astroglial proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Prion protein peptide neurotoxicity can be mediated by astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Alteration of free radical metabolism in the brain of mice infected with scrapie agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Neuronal apoptosis in Creutzfeldt-Jakob disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Astrocytosis and amyloid deposition in scrapie-infected hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Transmission of BSE by blood transfusion in sheep

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Eight prion strains have PrP(Sc) molecules with different conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Binding of disease-associated prion protein to plasminogen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Plasminogen binds to disease-associated prion protein of multiple species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

A protease-resistant prion protein isoform is present in urine of animals and humans affected with prion diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

The anti-prion activity of Congo red. Putative mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Controlling polymerization of beta-amyloid and prion-derived peptides with synthetic small molecule ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Effectiveness of anthracycline against experimental prion disease in Syrian hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Prion (PrPSc)-specific epitope defined by a monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Elimination of prions by branched polyamines and implications for therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Branched polyamines cure prion-infected neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Mimicking dominant negative inhibition of prion replication through structure-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Effect of amphotericin B on wild-type and mutated prion proteins in cultured cells: putative mechanism of action in transmissible spongiform encephalopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Vaccination with an attenuated Creutzfeldt-Jakob disease strain prevents expression of a virulent agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Potent inhibition of scrapie-associated PrP accumulation by congo red

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Porphyrin and phthalocyanine antiscrapie compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Transmissible and genetic prion diseases share a common pathway of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Protease-resistant and detergent-insoluble prion protein is not necessarily associated with prion infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Pathogenesis of Scrapie in the Mouse: the Role of the Spleen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Studies of the lymphoreticular system in the pathogenesis of scrapie: The role of spleen and thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Amphotericin B: new life for an old drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Ionising radiation has no influence on scrapie incubation period in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Effect of Sinc genotype, agent isolate and route of infection on the accumulation of protease-resistant PrP in non-central nervous system tissues during the development of murine scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Protease-resistant PrP deposition in brain and non-central nervous system tissues of a murine model of bovine spongiform encephalopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

The Reticuloendothelial System in Scrapie Pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Prolongation of scrapie incubation period by an injection of dextran sulphate 500 within the month before or after infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Sulphate polyanions prolong the incubation period of scrapie-infected hamsters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Chemoprophylaxis of scrapie in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Inhibition of scrapie-associated PrP accumulation. Probing the role of glycosaminoglycans in amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Selective inhibition of immune complex trapping by follicular dendritic cells with monoclonal antibodies against rat C3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

The role of complement in the acquired immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Complement facilitates early prion pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Neuronal cell death in scrapie-infected mice is due to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Evidence for an early inflammatory response in the central nervous system of mice with scrapie.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Early loss of dendritic spines in murine scrapie revealed by confocal analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Apoptosis and dendritic dysfunction precede prion protein accumulation in 87V scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Prion protein genes and prion diseases: studies in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Early behavioural changes in scrapie-affected mice and the influence of dapsone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Conditionally immortal neuroepithelial stem cell grafts reverse age-associated memory impairments in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Fetal cell grafts provide long-term protection against scrapie induced neuronal loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Predicted vCJD mortality in Great Britain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Sphingolipid Depletion Increases Formation of the Scrapie Prion Protein in Neuroblastoma Cells Infected with Prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

PrP expression in B lymphocytes is not required for prion neuroinvasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Straining the prion hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

Turning off follicular dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.5.569

21 January 2018

Identifiers

DOI

10.1517/14728222.5.5.569

1 reference

6 August 2017

1 reference