Novel chemical genetic approaches to the discovery of signal transduction inhibitors (Q35053197)

6 August 2017

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title

Novel chemical genetic approaches to the discovery of signal transduction inhibitors (English)

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6 August 2017

Kevan Shokat

1

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PubMed ID

12546954

6 August 2017

Mark Velleca

series ordinal

2

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6 August 2017

1 August 2002

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6 August 2017

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6 August 2017

7

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6 August 2017

16

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6 August 2017

872-879

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Chemogenomic approaches to drug discovery

6 August 2017

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The challenges of translating knockout phenotypes into gene function

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Unnatural ligands for engineered proteins: new tools for chemical genetics

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Controlling signaling with a specifically designed Gi-coupled receptor

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Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice

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Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides

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Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR

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The estrogen receptor: a structure-based approach to the design of new specific hormone-receptor combinations.

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Controlling signal transduction with synthetic ligands

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TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins

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7 January 2021

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

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Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins

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Rapid targeting of nuclear proteins to the cytoplasm

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Dimeric ligands define a role for transcriptional activation domains in reinitiation

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Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

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Designing small-molecule switches for protein-protein interactions

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Magic bullets for protein kinases

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A chemical switch for inhibitor-sensitive alleles of any protein kinase

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Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme

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Engineering Src family protein kinases with unnatural nucleotide specificity

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Design of allele-specific inhibitors to probe protein kinase signaling

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Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p

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Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response

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Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.

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A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway

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Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs

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A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

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Allele-specific activators and inhibitors for kinesin

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7 January 2021

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Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12546954