Therapeutic potential of protease-activated receptor-1 antagonists (Q35056060)

6 August 2017

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title

Therapeutic potential of protease-activated receptor-1 antagonists (English)

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6 August 2017

Claudia K Derian

1

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6 August 2017

Bruce E Maryanoff

series ordinal

2

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6 August 2017

Han-Cheng Zhang

series ordinal

3

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6 August 2017

Patricia Andrade-Gordon

series ordinal

4

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6 August 2017

language of work or name

English

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publication date

1 February 2003

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Expert Opinion on Investigational Drugs

6 August 2017

published in

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6 August 2017

volume

12

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6 August 2017

issue

2

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6 August 2017

page(s)

209-221

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Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization

6 August 2017

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21 January 2018

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail

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Molecular cloning of a potential proteinase activated receptor

21 January 2018

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Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

21 January 2018

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Protease-activated receptor 3 is a second thrombin receptor in humans

21 January 2018

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Cloning and characterization of human protease-activated receptor 4

21 January 2018

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Ligand cross-reactivity within the protease-activated receptor family.

21 January 2018

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Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

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Role of the thrombin receptor in development and evidence for a second receptor.

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A role for thrombin receptor signaling in endothelial cells during embryonic development

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PAR3 is a cofactor for PAR4 activation by thrombin

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Role of thrombin signalling in platelets in haemostasis and thrombosis

21 January 2018

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Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion

21 January 2018

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Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha

21 January 2018

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Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists

21 January 2018

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The role of secondary growth factor production in thrombin-induced proliferation of vascular smooth muscle cells

21 January 2018

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Human mast cell tryptase: a stimulus of microvascular leakage and mast cell activation.

21 January 2018

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Thrombin enhances monocyte secretion of tumor necrosis factor and interleukin-1 beta by two distinct mechanisms

21 January 2018

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Thrombin functions as an inflammatory mediator through activation of its receptor

21 January 2018

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Pro- and anti-inflammatory actions of thrombin: a distinct role for proteinase-activated receptor-1 (PAR1).

21 January 2018

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Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism

21 January 2018

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Protection against thrombosis in mice lacking PAR3.

21 January 2018

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Thrombin receptor antagonists; recent advances in PAR-1 antagonist development

21 January 2018

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The cleaved peptide of the thrombin receptor is a strong platelet agonist

21 January 2018

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The thrombin receptor extracellular domain contains sites crucial for peptide ligand-induced activation

21 January 2018

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Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates

21 January 2018

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Potent, low molecular weight thrombin receptor antagonists

21 January 2018

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Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).

21 January 2018

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G alpha minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation

21 January 2018

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Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

21 January 2018

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Intimal hyperplasia following vascular injury is not inhibited by an antisense thrombin receptor oligodeoxynucleotide

21 January 2018

1 reference

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10.1517/13543784.12.2.209

21 January 2018

Identifiers

DOI

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6 August 2017

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