The complementary roles of deletion and regulation in transplantation tolerance (Q35058547)

6 August 2017

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title

The complementary roles of deletion and regulation in transplantation tolerance (English)

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6 August 2017

Robert I Lechler

1

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6 August 2017

Oliver A Garden

series ordinal

2

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6 August 2017

Laurence A Turka

series ordinal

3

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6 August 2017

publication date

1 February 2003

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Nature Reviews Immunology

6 August 2017

published in

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6 August 2017

volume

3

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6 August 2017

issue

2

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6 August 2017

page(s)

147-158

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Actively acquired tolerance of foreign cells

6 August 2017

cites work

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31 March 2020

The homograft reaction

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Failure of long surviving, passively enhanced kidney allografts to provoke T-dependent alloimmunity. I. Retransplantation of (AS X AUG)F1 kidneys into secondary AS recipients

31 March 2020

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Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells

31 March 2020

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Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question

31 March 2020

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A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR.

31 March 2020

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Are primary alloresponses truly primary?

31 March 2020

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Allorecognition of HLA-DR and -DQ transfectants by human CD45RA and CD45R0 CD4 T cells: repertoire analysis and activation requirements

31 March 2020

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High determinant density may explain the phenomenon of alloreactivity

31 March 2020

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Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?

31 March 2020

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The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules

31 March 2020

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The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice

31 March 2020

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Strong and weak histocompatibility gene differences in mice and their role in the rejection of homografts of tumors and skin

31 March 2020

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Indirect T cell allorecognition of donor antigens contributes to the rejection of vascularized kidney allografts

31 March 2020

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Acute rejection in the absence of cognate recognition of allograft by T cells

31 March 2020

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Induction of T-cell response to cryptic MHC determinants during allograft rejection.

31 March 2020

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Evidence that human cardiac allograft acceptance is associated with a decrease in donor-reactive helper T lymphocytes

31 March 2020

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Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans

31 March 2020

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Loss of Direct and Maintenance of Indirect Alloresponses in Renal Allograft Recipients: Implications for the Pathogenesis of Chronic Allograft Nephropathy

31 March 2020

1 reference

Indirect allorecognition of donor HLA-DR peptides in chronic rejection of heart allografts

31 March 2020

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Why do we reject a graft? Role of indirect allorecognition in graft rejection

31 March 2020

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Indirect allorecognition of mismatched donor HLA class II peptides in lung transplant recipients with bronchiolitis obliterans syndrome

31 March 2020

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Suppressor T cells in rats with prolonged cardiac allograft survival after treatment with cyclosporine

31 March 2020

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Mechanisms maintaining enhancement of allografts. I. Demonstration of a specific suppressor cell

31 March 2020

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Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action

31 March 2020

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Oral antigen induces allograft survival by linked suppression via the indirect pathway

31 March 2020

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CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade

31 March 2020

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Identification of regulatory T cells in tolerated allografts

31 March 2020

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Regulatory T cells in transplantation.

31 March 2020

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Ly-1 inducer and Ly-1,2 acceptor t cells in the feedback suppression circuit bear an I-J-subregion controlled determinant

31 March 2020

1 reference

Suppressor T cells: some answers but more questions

31 March 2020

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Saying the 'S' word in public.

31 March 2020

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Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.

31 March 2020

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Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance

31 March 2020

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Requirement for natural killer T (NKT) cells in the induction of allograft tolerance

31 March 2020

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

31 March 2020

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Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

31 March 2020

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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

31 March 2020

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IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

31 March 2020

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Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected].

31 March 2020

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Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells

31 March 2020

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Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4

31 March 2020

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Effect of one-HLA-DR-antigen-matched and completely HLA-DR-mismatched blood transfusions on survival of heart and kidney allografts

31 March 2020

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Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat

31 March 2020

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Phenotypic analysis of oral tolerance to alloantigens: evidence that the indirect pathway of antigen presentation is involved

31 March 2020

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Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade

31 March 2020

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T cell death and transplantation tolerance.

31 March 2020

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Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells

31 March 2020

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CD4(+), CD25(+) T cells as regulators of alloimmune responses

31 March 2020

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Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells.

31 March 2020

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Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance

31 March 2020

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Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size

31 March 2020

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Mixed chimerism and transplant tolerance

31 March 2020

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IMMUNOGENETIC CONSEQUENCES OF VASCULAR ANASTOMOSES BETWEEN BOVINE TWINS

31 March 2020

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Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts

31 March 2020

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Mixed chimerism as an approach for the induction of transplantation tolerance

31 March 2020

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Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance

31 March 2020

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Promotion of rat cardiac allograft survival by intrathymic inoculation of donor splenocytes

31 March 2020

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Induction of donor-specific unresponsiveness by intrathymic islet transplantation

31 March 2020

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Dissociation of hemopoietic chimerism and allograft tolerance after allogeneic bone marrow transplantation

31 March 2020

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Induction of tolerance by monoclonal antibody therapy

31 March 2020

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Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

31 March 2020

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Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

31 March 2020

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Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8

31 March 2020

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Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

31 March 2020

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Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1

31 March 2020

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Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production

31 March 2020

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Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation

31 March 2020

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The B7 and CD28 receptor families

31 March 2020

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T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo

31 March 2020

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Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion

31 March 2020

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A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells

31 March 2020

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The role of CD40 in the regulation of humoral and cell-mediated immunity

31 March 2020

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Expression of functional CD40 by vascular endothelial cells

31 March 2020

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Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1

31 March 2020

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Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease

31 March 2020

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CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway

31 March 2020

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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

31 March 2020

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Targeting signal 1 through CD45RB synergizes with CD40 ligand blockade and promotes long term engraftment and tolerance in stringent transplant models

31 March 2020

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Prevention and reversal of renal allograft rejection by antibody against CD45RB

31 March 2020

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New developments in immunosuppressive therapy in renal transplantation

31 March 2020

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Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

31 March 2020

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

31 March 2020

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

31 March 2020

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

31 March 2020

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Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

31 March 2020

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Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

31 March 2020

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Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.

31 March 2020

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Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death

31 March 2020

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Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance.

31 March 2020

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Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model

31 March 2020

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Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs

31 March 2020

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Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice.

31 March 2020

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Immunological tolerance as an adjunct to allogeneic tissue grafting

31 March 2020

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Peritransplant tolerance induction in macaques: early events reflecting the unique synergy between immunotoxin and deoxyspergualin

31 March 2020

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Durable donor-specific T and B cell tolerance in rhesus macaques induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin: absence of chronic allograft nephropathy

31 March 2020

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CAMPATH IH ALLOWS LOW-DOSE CYCLOSPORINE MONOTHERAPY IN 31 CADAVERIC RENAL ALLOGRAFT RECIPIENTS

31 March 2020

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Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen

31 March 2020

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Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

31 March 2020

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Mechanisms of transplant tolerance induction using costimulatory blockade

31 March 2020

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Selective activation of the calcium signaling pathway by altered peptide ligands

31 March 2020

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Regulation of the IL-10 production by human T cells.

31 March 2020

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Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis

31 March 2020

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Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms

31 March 2020

1 reference

Sirolimus: a comprehensive review

31 March 2020

1 reference

Rapamycin: clinical results and future opportunities

31 March 2020

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CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

31 March 2020

1 reference

Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus.

31 March 2020

1 reference

Immunodominance in the T-cell response to multiple non-H-2 histocompatibility antigens. II. Observation of a hierarchy among dominant antigens

31 March 2020

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CD4+ CD25+ suppressor T cells: more questions than answers

31 March 2020

1 reference

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

31 March 2020

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Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells

31 March 2020

1 reference

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

31 March 2020

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Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

31 March 2020

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Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

31 March 2020

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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

31 March 2020

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Effect of organ culture on the survival of thyroid allografts in mice

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1002

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6 August 2017

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