Effective drug delivery by PEGylated drug conjugates (Q35058925)

6 August 2017

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title

Effective drug delivery by PEGylated drug conjugates (English)

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6 August 2017

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Richard B Greenwald

1

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6 August 2017

Yun H Choe

series ordinal

2

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6 August 2017

Jeffrey McGuire

series ordinal

3

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6 August 2017

Charles D Conover

series ordinal

4

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6 August 2017

language of work or name

English

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publication date

1 February 2003

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Advanced Drug Delivery Reviews

6 August 2017

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6 August 2017

55

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6 August 2017

2

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6 August 2017

217-250

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Colloid osmotic properties of modified hemoglobins: chemically cross-linked versus polyethylene glycol surface-conjugated

6 August 2017

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7 January 2021

Polyethylene glycol induces apoptosis in HT-29 cells: potential mechanism for chemoprevention of colon cancer

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7 January 2021

Soluble polymer-supported organic synthesis

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7 January 2021

Higher Antitumor Efficacy of Daunomycin When Linked to Dextran: In Vivo and In Vitro Studies 2

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7 January 2021

Phase I clinical and pharmacokinetic trial of dextran conjugated doxorubicin (AD-70, DOX-OXD).

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7 January 2021

Anti-tumor activity of daunorubicin linked to poly-L-aspartic acid

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7 January 2021

Functionalized semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] for protein modification

1 reference

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7 January 2021

PEG thiazolidine-2-thione, a novel reagent for facile protein modification: conjugation of bovine hemoglobin

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7 January 2021

Identification of the major positional isomer of pegylated interferon alpha-2b

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7 January 2021

Structural and biologic characterization of pegylated recombinant IFN-alpha2b

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7 January 2021

Carboxyalkylated histidine is a pH-dependent product of pegylation with SC-PEG.

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7 January 2021

Peginterferon alfa-2a (40 kDa) monotherapy: a novel agent for chronic hepatitis C therapy

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7 January 2021

A branched monomethoxypoly(ethylene glycol) for protein modification

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7 January 2021

Filgrastim (r-metHuG-CSF) in the 21st century: SD/01.

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7 January 2021

Blinded, randomized, multicenter study to evaluate single administration pegfilgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III/IV breast cancer

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7 January 2021

The use of polyethylene glycol-modified interleukin-2 (PEG-IL-2) in the treatment of patients with metastatic renal cell carcinoma and melanoma. A phase I study and a randomized prospective study comparing IL-2 alone versus IL-2 combined with PEG-IL

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900180-1

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7 January 2021

Pharmacokinetic disposition of polyethylene glycol-modified salmon calcitonins in rats

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7 January 2021

Amino acids and peptides. XXXII: A bifunctional poly(ethylene glycol) hybrid of fibronectin-related peptides

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7 January 2021

The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides.

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7 January 2021

Stability, specific binding activity, and plasma concentration in mice of an oligodeoxynucleotide modified at 5'-terminal with poly(ethylene glycol).

1 reference

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7 January 2021

Synthesis and characterization of high-molecular mass polyethylene glycol-conjugated oligonucleotides

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7 January 2021

Synthesis and properties of oligodeoxyribonucleotide-polyethylene glycol conjugates

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900180-1

7 January 2021

Oligonucleotide conjugated to linear and branched high molecular weight polyethylene glycol as substrates for RNase H.

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7 January 2021

Antigene effect in K562 cells of a PEG-conjugated triplex-forming oligonucleotide targeted to the bcr/abl oncogene

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7 January 2021

Prolonged circulating lives of single-chain Fv proteins conjugated with polyethylene glycol: a comparison of conjugation chemistries and compounds

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7 January 2021

Inhibition of tumor growth by poly(ethylene glycol) derivatives of anti-ErbB2 antibodies

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900180-1

7 January 2021

Modulating pharmacokinetics of an anti-interleukin-8 F(ab')(2) by amine-specific PEGylation with preserved bioactivity

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900180-1

7 January 2021

Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapy

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7 January 2021

Prodrugs. Do they have advantages in clinical practice?

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7 January 2021

Drug delivery systems: water soluble taxol 2'-poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness

1 reference

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7 January 2021

Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.

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7 January 2021

Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900180-1

7 January 2021

Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues.

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7 January 2021

Camptothecin delivery systems: enhanced efficacy and tumor accumulation of camptothecin following its conjugation to polyethylene glycol via a glycine linker

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7 January 2021

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo.

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7 January 2021

Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs

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7 January 2021

Drug delivery systems. 2. Camptothecin 20-O-poly(ethylene glycol) ester transport forms

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7 January 2021

20-O-acylcamptothecin derivatives: evidence for lactone stabilization.

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7 January 2021

The synthesis of lignans and neolignans

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7 January 2021

Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin

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7 January 2021

Antitumor agents LXII: synthesis and biological evaluation of podophyllotoxin esters and related derivatives

1 reference

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7 January 2021

Drug delivery of anticancer agents: water soluble 4-poly (ethylene glycol) derivatives of the lignan, podophyllotoxin

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7 January 2021

Camptothecin-20-PEG ester transport forms: the effect of spacer groups on antitumor activity

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7 January 2021

Synthesis, in vitro kinetics, and in vivo studies on protein conjugates of AZT: evaluation as a transport system to increase brain delivery.

1 reference

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7 January 2021

Intramolecular nucleophilic aminolysis of aliphatic esters. Cyclization of methyl 2-aminomethylbenzoate to phthalimidine

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7 January 2021

Cyclization-activated prodrugs. Basic carbamates of 4-hydroxyanisole

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7 January 2021

Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter

1 reference

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7 January 2021

Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir.

1 reference

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7 January 2021

Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity

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7 January 2021

Synthesis and evaluation of some water-soluble prodrugs and derivatives of taxol with antitumor activity

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https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900180-1

7 January 2021

Poly(ethylene glycol)-human serum albumin-paclitaxel conjugates: preparation, characterization and pharmacokinetics

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7 January 2021

Acid-sensitive polyethylene glycol conjugates of doxorubicin: preparation, in vitro efficacy and intracellular distribution

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7 January 2021

Drug delivery systems employing 1,4- or 1,6-elimination: poly(ethylene glycol) prodrugs of amine-containing compounds

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7 January 2021

Drug delivery systems based on trimethyl lock lactonization: poly(ethylene glycol) prodrugs of amino-containing compounds

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7 January 2021

A novel connector linkage applicable in prodrug design

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7 January 2021

The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme-prodrug therapies.

1 reference

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7 January 2021

Synthesis and characterisation of a new amphotericin B-methoxypoly(ethylene glycol) conjugate

1 reference

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7 January 2021

Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?

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7 January 2021

Prodrug strategies based on intramolecular cyclization reactions

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7 January 2021

Design of intramolecularly activated prodrugs

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7 January 2021

The Pharmacology of Prodrugs of 5-Fluorouracil and 1-β-D-Arabinofuranosylcytosine

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7 January 2021

Novel oral fluoropyrimidines in the treatment of metastatic colorectal cancer.

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7 January 2021

Anticancer drug delivery systems: N4-acyl poly(ethyleneglycol) prodrugs of ara-C. I. Efficacy in solid tumors

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7 January 2021

Anticancer drug delivery systems: multi-loaded N4-acyl poly(ethylene glycol) prodrugs of ara-C. II. Efficacy in ascites and solid tumors

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7 January 2021

Chemoenzymatic Synthesis of N-RasLipopeptides

1 reference

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7 January 2021

Drug delivery systems employing 1,6-elimination: releasable poly(ethylene glycol) conjugates of proteins

1 reference

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7 January 2021

Mucoadhesive drug carriers based on complexes of poly(acrylic acid) and PEGylated drugs having hydrolysable PEG–anhydride–drug linkages

1 reference

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7 January 2021

Synthesis of a novel duocarmycin derivative DU-257 and its application to immunoconjugate using poly(ethylene glycol)-dipeptidyl linker capable of tumor specific activation

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7 January 2021

Enhanced tumor cell selectivity of adriamycin-monoclonal antibody conjugate via a poly(ethylene glycol)-based cleavable linker

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7 January 2021

10.1016/S0169-409X(02)00180-1

Identifiers

DOI

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6 August 2017

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