Activated protein C up-regulates procoagulant tissue factor activity on endothelial cells by shedding the TFPI Kunitz 1 domain. (Q35067413)

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27 January 2020

title

Activated protein C up-regulates procoagulant tissue factor activity on endothelial cells by shedding the TFPI Kunitz 1 domain (English)

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27 January 2020

0 references

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1

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27 January 2020

author name string

Kara Velez

series ordinal

2

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27 January 2020

Matthias Riewald

series ordinal

3

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27 January 2020

language of work or name

English

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publication date

7 April 2011

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27 January 2020

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27 January 2020

volume

117

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27 January 2020

issue

23

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27 January 2020

page(s)

6338-6346

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Interdependent biological systems, multi-functional molecules: the evolving role of tissue factor pathway inhibitor beyond anti-coagulation

27 January 2020

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Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor.

8 July 2018

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Caveolae are required for protease-selective signaling by protease-activated receptor-1.

8 July 2018

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Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

8 July 2018

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Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin

8 July 2018

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Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

8 July 2018

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8 July 2018

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8 July 2018

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Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

8 July 2018

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A GPI-anchored co-receptor for tissue factor pathway inhibitor controls its intracellular trafficking and cell surface expression

8 July 2018

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8 July 2018

Sources of tissue factor

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8 July 2018

Tissue factor encryption

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Comparison of cell-surface TFPIalpha and beta

8 July 2018

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Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition

8 July 2018

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Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

8 July 2018

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Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3

8 July 2018

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Activation of endothelial cell protease activated receptor 1 by the protein C pathway

8 July 2018

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Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor

8 July 2018

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8 July 2018

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Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

8 July 2018

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Endothelial protein C receptor

8 July 2018

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The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries

8 July 2018

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Protein C activation on endothelial cells by prothrombin activation products generated in situ: meizothrombin is a better protein C activator than alpha-thrombin

8 July 2018

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Ligand-induced protease receptor translocation into caveolae: a mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway

8 July 2018

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Full-length human tissue factor pathway inhibitor inhibits human activated protein C in the presence of heparin

8 July 2018

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Permanent cell line expressing human factor VIII-related antigen established by hybridization

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Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor

8 July 2018

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8 July 2018

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Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1.

27 September 2018

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27 September 2018

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Formation of factors IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin III.

27 September 2018

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27 September 2018

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27 September 2018

The Protein C Pathway

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12 December 2020

Factor Xa cleavage of tissue factor pathway inhibitor is associated with loss of anticoagulant activity

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12 December 2020

Production and availability of thromboplastin in endothelial cells: the effects of thrombin, endotoxin and platelets

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12 December 2020

Immunoblotting studies of the molecular forms of protein C in plasma

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12 December 2020

Tissue factor pathway inhibitor

1 reference

12 December 2020

10.1182/BLOOD-2010-10-316257

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21474669%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

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27 January 2020

PubMed publication ID

21474669

1 reference