A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice. (Q35071632)

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English	A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice.	scientific article

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17 January 2020

A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice (English)

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17 January 2020

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glomerulonephritis

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inferred from title

11

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17 January 2020

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17 January 2020

David J Nikolic-Paterson

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17 January 2020

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Lin Leng

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17 January 2020

Liang Chen

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17 January 2020

Juan Fan

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17 January 2020

Dorothee Greven

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17 January 2020

Alvaro Arjona

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17 January 2020

Xin Du

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17 January 2020

David Austin

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17 January 2020

Michael Kashgarian

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17 January 2020

Zhinan Yin

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17 January 2020

Xiao R Huang

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17 January 2020

Richard Bucala

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17 January 2020

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24 November 2010

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17 January 2020

Journal of Immunology

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17 January 2020

186

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17 January 2020

1

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17 January 2020

527-538

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17 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3124407/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Biologics as treatment for systemic lupus: great efforts, sobering results, new challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

A functional heteromeric MIF receptor formed by CD74 and CXCR4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Subclinical atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Upregulation of macrophage migration inhibitory factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Role for macrophage migration inhibitory factor in asthma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Macrophage migration inhibitory factor: a regulator of innate immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

MIF signal transduction initiated by binding to CD74

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

A proinflammatory cytokine inhibits p53 tumor suppressor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Sustained mitogen-activated protein kinase (MAPK) and cytoplasmic phospholipase A2 activation by macrophage migration inhibitory factor (MIF). Regulatory role in cell proliferation and glucocorticoid action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

The pathogenic role of macrophage migration inhibitory factor in immunologically induced kidney disease in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Migration inhibitory factor expression in experimentally induced endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

The immunoregulatory mediator macrophage migration inhibitory factor (MIF) catalyzes a tautomerization reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

De Novo renal expression of macrophage migration inhibitory factor during the development of rat crescentic glomerulonephritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Crystal structure of the macrophage migration inhibitory factor from rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

Mapping antibody binding sites on cytochrome c with synthetic peptides: are results representative of the antigenic structure of proteins?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

8 July 2018

A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

27 September 2018

Systemic lupus erythematosus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

27 September 2018

Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

27 September 2018

Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

27 September 2018

Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

27 September 2018

ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

27 September 2018

Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

27 September 2018

Macrophage migration inhibitory factor in systemic lupus erythematosus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

27 September 2018

G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated/memory phenotype CD4+ cells of older lupus mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

27 September 2018

Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124407

16 November 2018

Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of chronic colitis is dependent on the cytokine MIF

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-10 regulates murine lupus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A soluble gradient of endogenous monocyte chemoattractant protein-1 promotes the transendothelial migration of monocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of an orally active series of isoxazoline glycoprotein IIb/IIIa antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo blockade of macrophage migration inhibitory factor ameliorates acute experimental autoimmune encephalomyelitis by impairing the homing of encephalitogenic T cells to the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage migration inhibitory factor is involved in the pathogenesis of collagen type II-induced arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage migration inhibitory factor promoter polymorphisms and the clinical expression of scleroderma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21106847

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.1001767

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106847%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106847%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21106847%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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