The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits (Q35076675)

6 August 2017

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title

The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits (English)

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6 August 2017

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Lisa A Pitcher

1

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6 August 2017

Jennifer A Young

2

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6 August 2017

Meredith A Mathis

3

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6 August 2017

Philip C Wrage

4

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6 August 2017

Beatrix Bartók

5

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6 August 2017

Nicolai S C van Oers

6

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6 August 2017

1 February 2003

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6 August 2017

Immunological Reviews

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6 August 2017

191

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6 August 2017

47-61

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T cell receptor antagonists and partial agonists

6 August 2017

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Antigen receptor tail clue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

T cell receptor-mediated signs and signals governing T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Signal transduction by lymphocyte antigen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Proximal protein tyrosine kinases in immunoreceptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Profound block in thymocyte development in mice lacking p56lck

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Differential T-cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor zeta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Essential role for ZAP-70 in both positive and negative selection of thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Partially phosphorylated T cell receptor zeta molecules can inhibit T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

An unusual mechanism for ligand antagonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Role of phosphatases in lymphocyte activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Negative regulation of immunoreceptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

The Sequence of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Form and function in protein dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Combinatorial control of the specificity of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Molecular basis of T cell inactivation by CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Immune signalling: SHP-2 docks at multiple ports

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Genetic analysis of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Switching signals on or off by receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Subcellular localization of intracellular protein tyrosine phosphatases in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) zeta subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR zeta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Evaluation of two-dimensional phosphopeptide maps by electrospray ionization mass spectrometry of recovered peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Protein tyrosine phosphatases: counting the trees in the forest

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

The YXXL signalling motifs of the bovine leukemia virus transmembrane protein are required for in vivo infection and maintenance of high viral loads

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Complex complexes: signaling at the TCR.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Molecular cloning of the zeta chain of the T cell antigen receptor.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

T cell development in mice that lack the zeta chain of the T cell antigen receptor complex

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

The Syk family of protein tyrosine kinases in T-cell activation and development

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor zeta subunits and the CD3 gamma, delta and epsilon chains

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

ITAM multiplicity and thymocyte selection: how low can you go?

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Role of TCR zeta chain in T cell development and selection

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Mature T cell reactivity altered by peptide agonist that induces positive selection

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Turnover of naive- and memory-phenotype T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

The emerging role of CTLA-4 as an immune attenuator

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00003.X

7 January 2021

10.1034/J.1600-065X.2003.00003.X

Identifiers

DOI

1 reference

6 August 2017

1 reference