Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration (Q35084405)

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English	Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration	scientific article

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scholarly article

1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration (English)

1 reference

Europe PubMed Central

6 August 2017

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mitochondrial DNA

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author name string

Fong-Qi Liang

1

1 reference

Europe PubMed Central

6 August 2017

Bernard F Godley

2

1 reference

Europe PubMed Central

6 August 2017

publication date

1 April 2003

1 reference

Europe PubMed Central

6 August 2017

Experimental Eye Research

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Europe PubMed Central

6 August 2017

76

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Europe PubMed Central

6 August 2017

4

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Europe PubMed Central

6 August 2017

397-403

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Europe PubMed Central

6 August 2017

Comparative effects of linoleic acid and linoleic acid hydroperoxide on growth and morphology of bovine retinal pigment epithelial cells in vitro

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7 January 2021

Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration

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7 January 2021

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8

1 reference

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7 January 2021

Simulation of free radical reactions in biology and medicine: a new two-compartment kinetic model of intracellular lipid peroxidation.

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7 January 2021

Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells

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7 January 2021

Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells

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7 January 2021

The role of oxidative stress in the pathogenesis of age-related macular degeneration.

1 reference

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7 January 2021

Detection and quantification of oxidative adducts of mitochondrial DNA.

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7 January 2021

Oxidative damage and protection of the RPE.

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7 January 2021

Hydroperoxide metabolism in mammalian organs

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7 January 2021

Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines

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7 January 2021

Lower levels of vitamin C and carotenes in plasma of cigarette smokers

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7 January 2021

Free-radical chemistry of cigarette smoke and its toxicological implications

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7 January 2021

The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria

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7 January 2021

Mitochondria in organismal aging and degeneration

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7 January 2021

Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells

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7 January 2021

Sunlight and age-related macular degeneration. The Beaver Dam Eye Study

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7 January 2021

Sun exposure and age-related macular degeneration. An Australian case-control study

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7 January 2021

Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat

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7 January 2021

Repair of oxidative damage to DNA: enzymology and biology

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7 January 2021

Growth of cultured RPE and endothelial cells is inhibited by blue light but not green or red light

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7 January 2021

The role of apoptosis in age-related macular degeneration

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7 January 2021

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

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7 January 2021

Photophysical studies on human retinal lipofuscin.

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7 January 2021

Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation

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7 January 2021

Oxygen radical chemistry of polyunsaturated fatty acids

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7 January 2021

Bcl-2 overexpression increases survival in human retinal pigment epithelial cells exposed to H(2)O(2).

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7 January 2021

Age-related macular degeneration histopathologic studies. The 1992 Lorenz E. Zimmerman Lecture

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7 January 2021

Pathologic features of senile macular degeneration

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7 January 2021

Cigarette smoking and retinal carotenoids: implications for age-related macular degeneration.

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7 January 2021

The aging process

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7 January 2021

Apoptosis in surgically excised choroidal neovascular membranes in age-related macular degeneration.

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7 January 2021

Hydrogen peroxide stimulates apoptosis in cultured human retinal pigment epithelial cells

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7 January 2021

Rod outer segments mediate mitochondrial DNA damage and apoptosis in human retinal pigment epithelium

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7 January 2021

Genetic risk of age-related maculopathy. Population-based familial aggregation study

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7 January 2021

Prevalence of age-related maculopathy. The Beaver Dam Eye Study

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7 January 2021

Heredity and age-related macular degeneration. Observations in monozygotic twins

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7 January 2021

Antioxidant enzymes in the aging human retinal pigment epithelium

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7 January 2021

DNA damage in brain mitochondria caused by aging and MPTP treatment.

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7 January 2021

Mitochondrial DNA repair and aging

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7 January 2021

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

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7 January 2021

Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species.

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7 January 2021

Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator of hydrogen peroxide in human fibroblasts

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7 January 2021

Relative susceptibilities of mitochondrial and nuclear DNA to damage induced by hydrogen peroxide in two mouse germ cell lines

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Vitamins, minerals, and macular degeneration. Promising but unproven hypotheses

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Familial aggregation of age-related maculopathy.

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SV40-immortalized and primary cultured human retinal pigment epithelial cells share similar patterns of cytokine-receptor expression and cytokine responsiveness

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7 January 2021

Smoking and age-related maculopathy. The Blue Mountains Eye Study

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7 January 2021

Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins

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7 January 2021

Lipid peroxidation product, 4-hydroxynonenal and its conjugate with GSH are excellent substrates of bovine lens aldose reductase

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Protein oxidation and aging

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Preventive effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye

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Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

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7 January 2021

Identifiers

10.1016/S0014-4835(03)00023-X

1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

6 August 2017

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