Mechanisms of plaque vulnerability and rupture (Q35088065)

6 August 2017

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title

Mechanisms of plaque vulnerability and rupture (English)

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6 August 2017

Prediman K Shah

1

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PubMed ID

12644336

6 August 2017

language of work or name

English

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publication date

1 February 2003

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Journal of the American College of Cardiology

6 August 2017

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6 August 2017

41

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6 August 2017

4 Suppl S

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6 August 2017

15S-22S

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Coronary plaque disruption.

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

The pathophysiology of acute coronary syndromes

1 reference

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7 January 2021

Current concepts of the pathogenesis of the acute coronary syndromes

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7 January 2021

Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction

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https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Coronary arteriographic findings soon after non-Q-wave myocardial infarction

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https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Significance of the angiographic morphology of localized coronary stenoses: histopathologic correlations

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7 January 2021

Coronary angioscopy in patients with unstable angina pectoris

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7 January 2021

Fibrin and fibrinogen-related antigens in patients with stable and unstable coronary artery disease

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7 January 2021

Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death

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7 January 2021

Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi

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7 January 2021

Angiographic morphology and the pathogenesis of unstable angina pectoris

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Coronary angiographic morphology in myocardial infarction: a link between the pathogenesis of unstable angina and myocardial infarction.

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7 January 2021

Anatomic-physiologic links between acute coronary syndromes

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7 January 2021

Pathogenesis of Coronary Thrombosis, Intramural and Intraluminal Hemorrhage

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7 January 2021

Quantitative and qualitative effects of intracoronary streptokinase in unstable angina and non-Q wave infarction

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7 January 2021

Angiographic evolution of coronary artery morphology in unstable angina

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7 January 2021

Significance of intraluminal filling defects in unstable angina

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7 January 2021

Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease?

1 reference

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7 January 2021

Pre-existing coronary stenoses in patients with first myocardial infarction are not necessarily severe

1 reference

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7 January 2021

Relation of the site of acute myocardial infarction to the most severe coronary arterial stenosis at prior angiography

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7 January 2021

Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B

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7 January 2021

Does the presence and site of myocardial ischemia on perfusion scintigraphy predict the occurrence and site of future myocardial infarction in patients with stable coronary artery disease?

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7 January 2021

Extent and direction of arterial remodeling in stable versus unstable coronary syndromes : an intravascular ultrasound study

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https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Plaque distribution and vascular remodeling of ruptured and nonruptured coronary plaques in the same vessel: an intravascular ultrasound study in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Mechanical and structural characteristics of vulnerable plaques: analysis by coronary angioscopy and intravascular ultrasound.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels

1 reference

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7 January 2021

Development of the lipid-rich core in human atherosclerosis

1 reference

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7 January 2021

Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques

1 reference

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7 January 2021

Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Relation of plaque lipid composition and morphology to the stability of human aortic plaques.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Collagen types I and III, collagen content, GAGs and mechanical strength of human atherosclerotic plaque caps: span-wise variations

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Macrophages, smooth muscle cells, and tissue factor in unstable angina. Implications for cell-mediated thrombogenicity in acute coronary syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Atherosclerotic plaque caps are locally weakened when macrophages density is increased

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Neovascularization in human coronary atherosclerotic lesions.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Neovascularization in atherectomy specimens from patients with unstable angina: implications for pathogenesis of unstable angina.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Mechanical properties of model atherosclerotic lesion lipid pools

1 reference

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7 January 2021

The impact of calcification on the biomechanical stability of atherosclerotic plaques

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7 January 2021

Identification of genes potentially involved in rupture of human atherosclerotic plaques

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7 January 2021

Stimulation of platelets and endothelial cells by mildly oxidized LDL proceeds through activation of lysophosphatidic acid receptors and the Rho/Rho-kinase pathway. Inhibition by lovastatin

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Tissue factor modulates the thrombogenicity of human atherosclerotic plaques.

1 reference

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7 January 2021

Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques

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7 January 2021

Local inhibition of tissue factor reduces the thrombogenicity of disrupted human atherosclerotic plaques: effects of tissue factor pathway inhibitor on plaque thrombogenicity under flow conditions.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Characterization of the relative thrombogenicity of atherosclerotic plaque components: Implications for consequences of plaque rupture

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology

1 reference

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7 January 2021

Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction

1 reference

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7 January 2021

Mast cell infiltration in acute coronary syndromes: implications for plaque rupture

1 reference

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7 January 2021

Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery

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7 January 2021

Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis

1 reference

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7 January 2021

Neovascularization and coronary atherosclerotic plaque: cinematographic localization and quantitative histologic analysis

1 reference

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7 January 2021

Rupture of coronary vasa vasorum as a trigger of acute myocardial infarction

1 reference

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7 January 2021

Blood flow through vasa vasorum of coronary arteries in atherosclerotic monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Microscopic localization of active proteases by in situ zymography: detection of matrix metalloproteinase activity in vascular tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human monocyte-derived macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques: evidence for activation by proinflammatory mediators

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinase

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Role of inflammation and metalloproteinases in plaque disruption and thrombosis

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis. Implications for plaque rupture

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Enhanced expression of vascular matrix metalloproteinases induced in vitro by cytokines and in regions of human atherosclerotic lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

T lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanism: implications for tubule formation

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: a role for CD40 signaling in plaque rupture?

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Tenascin-C is expressed in macrophage-rich human coronary atherosclerotic plaque

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Cystatin C deficiency in human atherosclerosis and aortic aneurysms

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

The role of apoptosis in vascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Cell death in human atherosclerotic plaques involves both oncosis and apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Oxidized LDLs alter the activity of the ubiquitin-proteasome pathway: potential role in oxidized LDL-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Apoptosis in the vascular wall and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Fas is expressed in human atherosclerotic intima and promotes apoptosis of cytokine-primed human vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Apoptosis in the vasculature: mechanisms and functional importance

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Triggering of plaque disruption and arterial thrombosis in an atherosclerotic rabbit model.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Animal model that mimics atherosclerotic plaque rupture.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Advanced atherosclerotic lesions in the innominate artery of the ApoE knockout mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Spontaneous plaque rupture and secondary thrombosis in apolipoprotein E-deficient and LDL receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Circadian variation and triggers of onset of acute cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Morning increase of onset of myocardial infarction. Implications concerning triggering events

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Triggering and hourly variation of onset of arterial thrombosis

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Sudden cardiac death. Support for a role of triggering in causation

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Increased particulate air pollution and the triggering of myocardial infarction

1 reference

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7 January 2021

Triggering myocardial infarction by marijuana

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7 January 2021

Circadian variation and triggering of acute coronary events

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Triggering of cardiac events by sexual activity: findings from a case-crossover analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Multiple Complex Coronary Plaques in Patients with Acute Myocardial Infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Smoking increases tissue factor expression in atherosclerotic plaques: implications for plaque thrombogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Coronary risk factors and plaque morphology in men with coronary disease who died suddenly

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Plaque stabilization: a mechanism for the beneficial effect of lipid-lowering therapies in angiography studies

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Pathophysiology of plaque rupture and the concept of plaque stabilization

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Vulnerable plaque: pathobiology and clinical implications

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Plaque stabilization: the role of lipid lowering

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Lipid lowering reduces proteolytic and prothrombotic potential in rabbit atheroma.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Recombinant apolipoprotein A-I Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Effects of recombinant apolipoprotein A-I(Milano) on aortic atherosclerosis in apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

High-dose recombinant apolipoprotein A-I(milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein e-deficient mice. Potential implications for acute plaque stabilization

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: an idea whose time for testing is coming, part I.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: an idea whose time for testing is coming, part II.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0735-1097%2802%2902834-6

7 January 2021

10.1016/S0735-1097(02)02834-6

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12644336