Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization (Q35095572)

6 August 2017

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization (English)

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6 August 2017

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7

C Ronald Kahn

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6 August 2017

1

Tatsuya Kondo

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6 August 2017

David Vicent

2

1 reference

6 August 2017

Kiyoshi Suzuma

3

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6 August 2017

Masashi Yanagisawa

4

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6 August 2017

George L King

5

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6 August 2017

Martin Holzenberger

6

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6 August 2017

language of work or name

English

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publication date

1 June 2003

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Journal of Clinical Investigation

6 August 2017

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6 August 2017

111

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6 August 2017

1835-1842

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6 August 2017

12

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The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Endothelial response to hypoxia: physiologic adaptation and pathologic dysfunction

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Endothelial exposure to hypoxia induces Egr-1 expression involving PKCalpha-mediated Ras/Raf-1/ERK1/2 pathway

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Hypoxia-associated induction of early growth response-1 gene expression

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Lowering the risk of visual impairment and blindness

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Protein kinase C activation and the development of diabetic complications

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Effects of ACE inhibition on spontaneous and insulin-stimulated endothelin-1 secretion: in vitro and in vivo studies

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Rapid tightening of blood glucose control leads to transient deterioration of retinopathy in insulin dependent diabetes mellitus: the Oslo study

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Role of endothelium-derived nitric oxide in the regulation of blood pressure

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Stimulation of endothelin-1 gene expression by insulin in endothelial cells.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Antigenic heterogeneity of vascular endothelium

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

The nitric oxide-cyclic GMP signal transduction pathway in vascular smooth muscle preparations and other tissues

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Retinal ischemia and angle neovascularization in proliferative diabetic retinopathy

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Captopril improves retinal neovascularization via endothelin-1.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Insulin stimulates both endothelin and nitric oxide activity in the human forearm.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

The 14-year incidence of visual loss in a diabetic population.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=161423

Effect of insulin therapy on progression of retinopathy in noninsulin-dependent diabetes mellitus

27 September 2018

1 reference

12 December 2020

Oxygen-induced retinopathy in the mouse

1 reference

12 December 2020

Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor

1 reference

12 December 2020

Insulin-induced vascular endothelial growth factor expression in retina

1 reference

12 December 2020

Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells

1 reference

12 December 2020

Nitric oxide mediates the mitogenic effects of insulin and vascular endothelial growth factor but not of leptin in endothelial cells

1 reference

12 December 2020

Vaso-obliteration in the canine model of oxygen-induced retinopathy

1 reference

12 December 2020

Localization of vascular endothelial growth factor in human retina and choroid

1 reference

12 December 2020

Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia

1 reference

12 December 2020

Retinopathy of prematurity: is suppression of neovascularization achievable?

1 reference

12 December 2020

The effect of glycaemic control and the introduction of insulin therapy on retinopathy in non-insulin-dependent diabetes mellitus

1 reference

12 December 2020

1 reference

12 December 2020

Early worsening of diabetic retinopathy in the Diabetes Control and Complications Trial

1 reference

12 December 2020

Changes in free insulin-like growth factor-1 and leptin concentrations during acute metabolic decompensation in insulin withdrawn patients with type 1 diabetes

1 reference

12 December 2020

Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI200317455

1 reference

6 August 2017

1 reference

6 August 2017

1 reference