Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. (Q35097448)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20627083%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors (English)

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7 February 2020

1

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7 February 2020

Kristine Freude

series ordinal

2

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7 February 2020

author name string

Shelley B Nelson

series ordinal

3

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7 February 2020

Maike Sander

series ordinal

4

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7 February 2020

language of work or name

English

0 references

publication date

1 June 2010

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7 February 2020

number of pages

8

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based on heuristic

inferred from page(s)

published in

Developmental Cell

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7 February 2020

volume

18

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7 February 2020

issue

6

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7 February 2020

page(s)

1022-1029

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Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window

7 February 2020

cites work

1 reference

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On the origin of the beta cell

9 July 2018

1 reference

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Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Reciprocal inhibition between Pax7 and muscle regulatory factors modulates myogenic cell fate determination

9 July 2018

1 reference

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Ptf1a determines horizontal and amacrine cell fates during mouse retinal development

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Notch signaling controls multiple steps of pancreatic differentiation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

The role of PTF1-P48 in pancreatic acinar gene expression

9 July 2018

1 reference

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Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube

9 July 2018

1 reference

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Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.

9 July 2018

1 reference

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Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Notch signalling controls pancreatic cell differentiation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth

9 July 2018

1 reference

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A multipotent progenitor domain guides pancreatic organogenesis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133668

Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.

27 September 2018

1 reference

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Multilineage transcriptional priming and determination of alternate hematopoietic cell fates.

27 September 2018

1 reference

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Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas

27 September 2018

1 reference

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Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.

27 September 2018

1 reference

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10.1016/J.DEVCEL.2010.05.015

27 September 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20627083%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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7 February 2020

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