Blood-brain equilibration kinetics of levo-alpha-acetyl-methadol using a chronically instrumented sheep preparation (Q35098619)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Blood-brain equilibration kinetics of levo-alpha-acetyl-methadol using a chronically instrumented sheep preparation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

author name string

Mette L Jensen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Richard N Upton

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Andrew A Somogyi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Cliff Grant

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Allison Martinez

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

language of work or name

English

0 references

publication date

1 January 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Pharmacology

9 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

volume

147

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

209-217

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

The acute disposition of (R)- and (s)-methadone in brain and lung of sheep

9 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

A MEDICAL TREATMENT FOR DIACETYLMORPHINE (HEROIN) ADDICTION. A CLINICAL TRIAL WITH METHADONE HYDROCHLORIDE.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

History and current status of opioid maintenance treatments: blending conference session

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Torsades de pointes associated with high dose levomethadyl acetate (ORLAAM).

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Isolation and mapping of the first ruminant multidrug resistance genes

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Patterns of symptom complaints in methadone maintenance patients.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Pharmacological basis for hepatic drug metabolism in sheep.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

An ultrasonic Doppler venous outflow method for the continuous measurement of cerebral blood flow in conscious sheep

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

α-1-Acetylmethadol and its N-demethylated metabolites have potent opiate action in the guinea pig isolated ileum

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Microelectrometric titration measurement of the pKa's and partition and drug distribution coefficients of narcotics and narcotic antagonists and their pH and temperature dependence

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Disposition of acetylmethadol in relation to pharmacologic action

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Pharmacology of l-alpha-acetylmethadol (LAAM) in subhuman primates

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Physiological disposition and biotransformation of l-alpha-[2-3H]acetylmethadol (LAAM) in acutely and chronically treated monkeys

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Recirculatory model of fentanyl disposition with the brain as the target organ

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individuals

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Cerebral and lung kinetics of morphine in conscious sheep after short intravenous infusions.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Interactions of the narcotic l-alpha-acetylmethadol with human cardiac K+ channels.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

The effect of altered cerebral blood flow on the cerebral kinetics of thiopental and propofol in sheep.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Agreement between ultrasonic Doppler venous outflow and Kety and Schmidt estimates of cerebral blood flow

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

Cardiac and autonomic nervous system effects of L-alphacetylmethadol (LAAM).

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1615857

The metabolism of alpha-dl-acetylmethadol in the rat: the identification of the probable active metabolite

27 September 2018

1 reference

12 December 2020

The analgesic activity of alpha-1-acetylmethadol and two of its metabolites in mice

1 reference

12 December 2020

Differential effects of phenobarbital on the constitutive and inducible expression of P450 2B and 3A subfamilies in sheep tissues

1 reference

12 December 2020

Plasma l-alpha-Acetylmethadol (LAAM) after acute and chronic administration

1 reference

12 December 2020

Effect of 1-alpha-acetylmethadol (LAAM) on various physiological parameters in the conscious dog

1 reference

12 December 2020

Dopaminergic and cholinergic muscarinic receptor effects of L-alphacetylmethadol (LAAM) and its metabolites

1 reference

12 December 2020

A SHEEP PREPARATION FOR STUDYING INTERACTIONS BETWEEN BLOOD FLOW AND DRUG DISPOSITION. I: PHYSIOLOGICAL PROFILE

1 reference

12 December 2020

L-alphacetylmethadol (LAAM) effects on cardiac muscarinic receptors

1 reference

12 December 2020

Systemic clearance and demethylation of caffeine in sheep and cattle

1 reference

12 December 2020

Intravenous and oral l-alpha-acetylmethadol: pharmacodynamics and pharmacokinetics in humans

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0706470

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299549%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

16299549

1 reference