Local renin-angiotensin systems: the unanswered questions (Q35099106)

6 August 2017

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title

Local renin-angiotensin systems: the unanswered questions (English)

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6 August 2017

A H Jan Danser

1

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6 August 2017

1 June 2003

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International Journal of Biochemistry & Cell Biology

6 August 2017

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6 August 2017

35

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6 August 2017

6

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6 August 2017

759-768

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Angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade prevent cardiac remodeling in pigs after myocardial infarction: role of tissue angiotensin II

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin production by the heart: a quantitative study in pigs with the use of radiolabeled angiotensin infusions.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Intrarenal angiotensin II: interstitial and cellular levels and site of production

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Activation of cardiac renin-angiotensin system in unstable angina

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Effect of bilateral nephrectomy on active renin, angiotensinogen, and renin glycoforms in plasma and myocardium.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Renin-angiotensin system components in the interstitial fluid of the isolated perfused rat heart. Local production of angiotensin I

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Cultured neonatal rat cardiac myocytes and fibroblasts do not synthesize renin or angiotensinogen: evidence for stretch-induced cardiomyocyte hypertrophy independent of angiotensin II.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Myocardial enzymatic activity of renin and cathepsin D before and after bilateral nephrectomy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin formation in the isolated rat hindlimb

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Induction of renin in medial smooth muscle cells by balloon injury

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Increased vascular angiotensin formation in female rats harboring the mouse Ren-2 gene

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Local angiotensin II generation in the rat heart: role of renin uptake.

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Renin is not synthesized by cardiac and extrarenal vascular tissues. A review of experimental evidence

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Arterial wall uptake of renal renin and blood pressure control

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Specific prorenin/renin binding (ProBP). Identification and characterization of a novel membrane site

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Molecular cloning and identification of N-acyl-D-glucosamine 2-epimerase from porcine kidney as a renin-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

The expression of renin-binding protein and renin in the kidneys of rats with two-kidney one-clip hypertension

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Cardiomyocytes bind and activate native human prorenin : role of soluble mannose 6-phosphate receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Is there a local renin-angiotensin system in the heart?

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Tissue activity of circulating prorenin

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Contribution of circulating renin to local synthesis of angiotensin peptides in the heart

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Effects of human prorenin in rats transgenic for human angiotensinogen

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Renin-angiotensin system and cell communication in the failing heart.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Intracellular Angiotensin II and cell growth of vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Detection of angiotensin I and II in cultured rat cardiac myocytes and fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin II type 1 (AT1) receptor-mediated accumulation of angiotensin II in tissues and its intracellular half-life in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Prorenin-induced myocyte proliferation: no role for intracellular angiotensin II.

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

In vitro evidence for an intracellular site of angiotensin action

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Subcellular localization of angiotensin II in kidney and adrenal

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

The angiotensin-converting enzyme gene family: genomics and pharmacology

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Isorenin, pseudorenin, cathepsin D and renin. A comparative enzymatic study of angiotensin-forming enzymes

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Nephrectomy, converting enzyme inhibition, and angiotensin peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Maximally recommended doses of angiotensin-converting enzyme (ACE) inhibitors do not completely prevent ACE-mediated formation of angiotensin II in chronic heart failure

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Reactive Hyperreninemia Is a Major Determinant of Plasma Angiotensin II During ACE Inhibition

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Gradual reactivation over time of vascular tissue angiotensin I to angiotensin II conversion during chronic lisinopril therapy in chronic heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Specific measurement of angiotensin metabolites and in vitro generated angiotensin II in plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Functional importance of angiotensin-converting enzyme-dependent in situ angiotensin II generation in the human forearm

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin converting enzyme is the main contributor to angiotensin I-II conversion in the interstitium of the isolated perfused rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Male–female differences in fertility and blood pressure in ACE-deficient mice

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Ramiprilat increases bradykinin outflow from isolated hearts of rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

L-NAME-resistant bradykinin-induced relaxation in porcine coronary arteries is NO-dependent: effect of ACE inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Bradykinin potentiation by angiotensin-(1-7) and ACE inhibitors correlates with ACE C- and N-domain blockade

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Comparison of zofenopril and lisinopril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE-inhibitors in experimental heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Losartan and its metabolite E3174 modify cardiac delayed rectifier K(+) currents

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Vasoconstriction is determined by interstitial rather than circulating angiotensin II

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https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Functional interaction between losartan and central tachykinin NK3 receptors in the conscious rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Interactions of nonpeptide angiotensin II receptor antagonists at imidazoline/guanidinium receptor sites in rat forebrain.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

The angiotensin II AT2 receptor is an AT1 receptor antagonist.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin II type 2 receptor gene transfer downregulates angiotensin II type 1a receptor in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Renin-angiotensin system gene polymorphisms: potential mechanisms for their association with cardiovascular diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Genotype-phenotype relationships for the renin-angiotensin-aldosterone system in a normal population

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

1166 A/C polymorphism of the angiotensin II type 1 receptor gene and the response to short-term infusion of angiotensin II

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensinogen (M235T) and angiotensin-converting enzyme (I/D) polymorphisms in association with plasma renin and prorenin levels.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin I to angiotensin II conversion in the human forearm and leg. Effect of the angiotensin converting enzyme gene insertion/deletion polymorphism

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Enhanced pressor response to angiotensin I in normotensive men with the deletion genotype (DD) for angiotensin-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

The angiotensin-converting enzyme gene polymorphism and responses to angiotensins and bradykinin in the human forearm

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Pressor and hormonal responses to angiotensin I infusion in healthy subjects of different angiotensin-converting enzyme genotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Left ventricular hypertrophy with exercise and ACE gene insertion/deletion polymorphism: a randomized controlled trial with losartan

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensinases restrict locally generated angiotensin II to the blood vessel wall.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900178-4

7 January 2021

10.1016/S1357-2725(02)00178-4

Identifiers

DOI

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6 August 2017

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PubMed ID

12676161