Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs (Q35100672)

6 August 2017

Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs (English)

1 reference

6 August 2017

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4

Daryl Staveness

1 reference

6 August 2017

Paul A Wender

1

1 reference

6 August 2017

Yu Nakagawa

series ordinal

2

1 reference

6 August 2017

Katherine E Near

series ordinal

3

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6 August 2017

language of work or name

English

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publication date

19 September 2014

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6 August 2017

4

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based on heuristic

inferred from page(s)

published in

Organic Letters

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6 August 2017

16

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6 August 2017

19

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6 August 2017

5136-5139

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Improved protein kinase C affinity through final step diversification of a simplified salicylate-derived bryostatin analog scaffold

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

New horizons for old drugs and drug leads

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Emerging strategies to deplete the HIV reservoir

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Bryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic stroke

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Protein kinase C pharmacology: refining the toolbox

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Recent developments in human immunodeficiency virus-1 latency research

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Protein kinase C, an elusive therapeutic target?

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Natural products as sources of new drugs over the 30 years from 1981 to 2010

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Total synthesis of bryostatin 7 via C-C bond-forming hydrogenation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Total synthesis of bryostatin 9

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Current status and future prospects of C1 domain ligands as drug candidates

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Total synthesis of bryostatin 1

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Bryostatins: biological context and biotechnological prospects.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Protein kinase C: poised to signal

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Synthesis at the molecular frontier

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Structural basis of protein kinase C isoform function

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Function-oriented synthesis, step economy, and drug design

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Macrolactonizations in the total synthesis of natural products

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Bryostatin-1: a novel PKC inhibitor in clinical development

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

The practical synthesis of a novel and highly potent analogue of bryostatin

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Novel "nonkinase" phorbol ester receptors: the C1 domain connection

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Total Synthesis of Bryostatin 3

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Computer-assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Bryostatin-1 promotes long-term potentiation via activation of PKCα and PKCε in the hippocampus.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

Aquaculture of three phyla of marine invertebrates to yield bioactive metabolites: process developments and economics

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334246

The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25238583

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antineoplastic Components of Marine Animals

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25238583

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/OL502491F

1 reference

6 August 2017

1 reference

6 August 2017

1 reference