pH regulation in Aspergillus and parallels with higher eukaryotic regulatory systems. (Q35102808)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12683976%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

review article

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title

pH regulation in Aspergillus and parallels with higher eukaryotic regulatory systems (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12683976%20AND%20SRC:MED&resulttype=core&format=json

Putative membrane protein involved in a signaling pathway that activates PacC transcription factor in response to alkaline ambient pH

2 November 2019

main subject

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Protein involved in a signaling pathway that activates PacC transcription factor in response to alkaline ambient pH

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Protein involved in a signaling pathway that activates PacC transcription factor in response to alkaline ambient pH

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Protein involved in a signaling pathway that activates PacC transcription factor in response to alkaline ambient pH

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Predicted calpain-like cysteine protease involved in a signaling pathway that activates PacC transcription factor in response to alkaline ambient pH

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C2H2 finger domain transcription factor

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author

Miguel A Penalva

series ordinal

2

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2 November 2019

author name string

Herbert N Arst

series ordinal

1

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2 November 2019

publication date

1 April 2003

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2 November 2019

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2 November 2019

volume

19

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2 November 2019

issue

4

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2 November 2019

page(s)

224-231

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Regulation of gene expression by ambient pH in filamentous fungi and yeasts

2 November 2019

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The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH.

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Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety

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Specific DNA recognition by the Aspergillus nidulans three zinc finger transcription factor PacC.

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Specificity determinants of proteolytic processing of Aspergillus PacC transcription factor are remote from the processing site, and processing occurs in yeast if pH signalling is bypassed

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Ambient pH signaling regulates nuclear localization of the Aspergillus nidulans PacC transcription factor

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Activation of the Aspergillus PacC zinc finger transcription factor requires two proteolytic steps.

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YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix

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Three binding sites for the Aspergillus nidulans PacC zinc-finger transcription factor are necessary and sufficient for regulation by ambient pH of the isopenicillin N synthase gene promoter

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Yeast PalA/AIP1/Alix homolog Rim20p associates with a PEST-like region and is required for its proteolytic cleavage

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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12683976%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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