Prophylactic thyroidectomy in multiple endocrine neoplasia: the impact of molecular mechanisms of RET proto-oncogene. (Q35104972)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12690476%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

review article

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title

Prophylactic thyroidectomy in multiple endocrine neoplasia: the impact of molecular mechanisms of RET proto-oncogene (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12690476%20AND%20SRC:MED&resulttype=core&format=json

multiple endocrine neoplasia

2 November 2019

main subject

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2

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2 November 2019

4

Christoph Erich Broelsch

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2 November 2019

author name string

Andrea Frilling

series ordinal

1

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2 November 2019

Carsten Tecklenborg

series ordinal

3

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2 November 2019

language of work or name

English

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publication date

25 March 2003

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Langenbeck's Archives of Surgery

2 November 2019

published in

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2 November 2019

volume

388

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2 November 2019

issue

1

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2 November 2019

page(s)

17-26

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A patient with MEN 2 and multiple mutations of RET in the germline

2 November 2019

cites work

1 reference

12 December 2020

Germline mutation of RET codon 883 in two cases of de novo MEN 2B.

1 reference

12 December 2020

The GDNF/RET signaling pathway and human diseases

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12 December 2020

Is thyroidectomy necessary in RET mutations carriers of the familial medullary thyroid carcinoma syndrome?

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12 December 2020

Various penetrance of familial medullary thyroid carcinoma in patients with RET protooncogene codon 790/791 germline mutations

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12 December 2020

Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

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12 December 2020

Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage

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12 December 2020

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

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12 December 2020

Prophylactic thyroidectomy in MEN 2A syndrome: experience in a single center

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12 December 2020

Genotype‐phenotype correlation in multiple endocrine neoplasia type 2: report of the International RET Mutation Consortium

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12 December 2020

Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers

1 reference

12 December 2020

Molecular genetic diagnostic program of multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma syndromes in Hungary

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12 December 2020

Differentiated and medullary thyroid cancer in childhood and adolescence

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12 December 2020

Characterization of a multicomponent receptor for GDNF.

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12 December 2020

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

1 reference

12 December 2020

Characterization of RET proto-oncogene 3' splicing variants and polyadenylation sites: a novel C-terminus for RET

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12 December 2020

Molecular genetic testing in pediatric practice: A subject review. Committee on Genetics

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12 December 2020

RET proto-oncogene mutations affecting codon 790/791: A mild form of multiple endocrine neoplasia type 2A syndrome?

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12 December 2020

Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation

1 reference

12 December 2020

Predictive DNA testing and prophylactic thyroidectomy in patients at risk for multiple endocrine neoplasia type 2A

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12 December 2020

Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene

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12 December 2020

Current national health insurance policies for thyroid cancer prophylactic surgery in the United States

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12 December 2020

Functional receptor for GDNF encoded by the c-ret proto-oncogene

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12 December 2020

Diagnostic and therapeutic approach to multiple endocrine neoplasia type 2B in pediatric patients.

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12 December 2020

A GTG to ATG novel point mutation at codon 804 in exon 14 of the RET proto-oncogene in two families affected by familial medullary thyroid carcinoma

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12 December 2020

Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma

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12 December 2020

A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A

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12 December 2020

GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF

1 reference

12 December 2020

Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret.

1 reference

12 December 2020

Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation

1 reference

12 December 2020

Differential interaction of Enigma protein with the two RET isoforms.

1 reference

12 December 2020

RET proto-oncogene mutations in French MEN 2A and FMTC families

1 reference

12 December 2020

Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains

1 reference

12 December 2020

Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells

1 reference

12 December 2020

A novel case of multiple endocrine neoplasia type 2A associated with two de novo mutations of the RET protooncogene

1 reference

12 December 2020

The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis

1 reference

12 December 2020

A RET double mutation in the germline of a kindred with FMTC.

1 reference

12 December 2020

Medullary thyroid carcinoma in children with multiple endocrine neoplasia types 2A and 2B.

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12 December 2020

Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis

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12 December 2020

Prophylactic thyroidectomy in 75 children and adolescents with hereditary medullary thyroid carcinoma: German and Austrian experience.

1 reference

12 December 2020

Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site

1 reference

12 December 2020

Genetic testing for familial cancer. Consequences of RET proto-oncogene mutation analysis in multiple endocrine neoplasia, type 2

1 reference

12 December 2020

The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

1 reference

12 December 2020

Early or prophylactic thyroidectomy in MEN 2/FMTC gene carriers: results in 71 thyroidectomized patients. The French Calcitonin Tumours Study Group (GETC).

1 reference

12 December 2020

Update on the MEN 2A c804 RET mutation: is prophylactic thyroidectomy indicated?

1 reference

12 December 2020

Early treatment of hereditary medullary thyroid carcinoma after attribution of multiple endocrine neoplasia type 2 gene carrier status by screening for ret gene mutations

1 reference

12 December 2020

Genetic and biochemical screening for endocrine disease: III. Costs and logistics.

1 reference

12 December 2020

RET mutations in exons 13 and 14 of FMTC patients

1 reference

12 December 2020

Variable expressivity of familial medullary thyroid carcinoma (FMTC) due to a RET V804M (GTG-->ATG) mutation

1 reference

12 December 2020

Prophylactic thyroidectomy for medullary thyroid carcinoma in gene carriers of MEN2 syndrome

1 reference

12 December 2020

A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A

1 reference

12 December 2020

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC.

1 reference

12 December 2020

Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex

1 reference

12 December 2020

Prophylactic thyroidectomy, based on direct genetic testing, in patients at risk for the multiple endocrine neoplasia type 2 syndromes

1 reference

12 December 2020

Familial medullary thyroid carcinoma: clinical variability and low aggressiveness associated with RET mutation at codon 804.

1 reference

12 December 2020

Predictive DNA testing for multiple endocrine neoplasia 2: a therapeutic challenge of prophylactic thyroidectomy in very young children

1 reference

12 December 2020

Familial medullary thyroid carcinoma with noncysteine ret mutations: phenotype-genotype relationship in a large series of patients

1 reference

12 December 2020

V804M RET mutation and familial medullary thyroid carcinoma: report of a large family with expression of the disease only in the homozygous gene carriers

1 reference

12 December 2020

Multiple endocrine neoplasia type 2B: more than an endocrine disorder

1 reference

12 December 2020

A nationwide clinical survey of patients with multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma in Japan.

1 reference

12 December 2020

A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC

1 reference

12 December 2020

A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10

1 reference

12 December 2020

Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

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12 December 2020

The RET proto‐oncogene and cancer

1 reference

12 December 2020

Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.

1 reference

12 December 2020

Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group

1 reference

12 December 2020

Familial Medullary Thyroid Carcinoma with Noncysteine RET Mutations: Phenotype-Genotype Relationship in a Large Series of Patients

1 reference

12 December 2020

10.1007/S00423-003-0368-4

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12690476%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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