Hepatitis C virus genetic variability: pathogenic and clinical implications (Q35105688)

6 August 2017

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title

Hepatitis C virus genetic variability: pathogenic and clinical implications (English)

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6 August 2017

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Jean-Michel Pawlotsky

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1

object named as

Jean-Michel Pawlotsky

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author name string

Jean-Michel Pawlotsky

series ordinal

1

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6 August 2017

1 February 2003

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6 August 2017

Clinics in liver disease

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6 August 2017

7

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6 August 2017

1

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6 August 2017

45-66

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

6 August 2017

1 reference

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7 January 2021

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

1 reference

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7 January 2021

Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Quasispecies and the implications for virus persistence and escape

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7 January 2021

The origin and evolution of hepatitis viruses in humans

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7 January 2021

Variability of the hepatitis C virus genome.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution

1 reference

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7 January 2021

Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization. International Committee on Virus Taxonomy

1 reference

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7 January 2021

Hepatitis C virus variants from Jakarta, Indonesia classifiable into novel genotypes in the second (2e and 2f), tenth (10a) and eleventh (11a) genetic groups

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus variants from Thailand classifiable into five novel genotypes in the sixth (6b), seventh (7c, 7d) and ninth (9b, 9c) major genetic groups

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus variants from Vietnam are classifiable into the seventh, eighth, and ninth major genetic groups

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Structural constraints on RNA virus evolution

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

The epidemic behavior of the hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Relationship between hepatitis C virus genotypes and sources of infection in patients with chronic hepatitis C.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Efficient initiation of HCV RNA replication in cell culture

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Characterization of cell lines carrying self-replicating hepatitis C virus RNAs

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Evolution of the hepatitis C virus second envelope protein hypervariable region in chronically infected patients receiving alpha interferon therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Changes in hepatitis C virus quasispecies and density populations in patients before and after interferon therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

The clinical significance of changes in genetic heterogeneity of the hypervariable region 1 in chronic hepatitis C with interferon therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Characterization of hypervariable regions in the putative envelope protein of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Comparison of hypervariable regions (HVR1 and HVR2) in positive- and negative-stranded hepatitis C virus RNA in cancerous and non-cancerous liver tissue, peripheral blood mononuclear cells and serum from a patient with hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Evolutionarily conserved RNA secondary structures in coding and non-coding sequences at the 3' end of the hepatitis G virus/GB-virus C genome.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Variation of the hepatitis C virus 5' non-coding region: implications for secondary structure, virus detection and typing. The International HCV Collaborative Study Group.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Quasispecies heterogeneity and constraints on the evolution of the 5' noncoding region of hepatitis C virus (HCV): relationship with HCV resistance to interferon-alpha therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Conservation of the Conformation and Positive Charges of Hepatitis C Virus E2 Envelope Glycoprotein Hypervariable Region 1 Points to a Role in Cell Attachment

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Nucleotide and amino acid complexity of hepatitis C virus quasispecies in serum and liver

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Nonrandom distribution of hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cell subsets

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Comparative analysis of translation efficiencies of hepatitis C virus 5' untranslated regions among intraindividual quasispecies present in chronic infection: opposite behaviors depending on cell type

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification. The International HCV Collaborative Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Heterogeneity of hepatitis C virus genotype 2 variants in West Central Africa (Guinea Conakry).

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Geographical distribution of hepatitis C virus genotypes in blood donors: an international collaborative survey

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

The complete coding sequence of hepatitis C virus genotype 5a, the predominant genotype in South Africa.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Distribution of hepatitis C virus genotypes among blood donors in Taiwan

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Complete coding sequence of hepatitis C virus genotype 6a.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Survey of type 6 group variants of hepatitis C virus in Southeast Asia by using a core-based genotyping assay

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus genotypes in France: relationship with epidemiology, pathogenicity and response to interferon therapy. The GEMHEP.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Epidemiology of hepatitis C virus infection in American veterans

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus genotypes in the United States: epidemiology, pathogenicity, and response to interferon therapy. Collaborative Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Prevalence of hepatitis C virus and distribution of its genotypes in Northern Eurasia.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Genotypes of hepatitis C virus in Guangxi province, southern China

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Genotype distribution in Nagoya and new genotype (genotype 3a) in Japanese patients with hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Evaluation of a new assay for hepatitis C virus genotyping and viral load determination in patients with chronic hepatitis C.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

The pathology of hepatitis C

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Pathology of hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. The Hepatitis Interventional Therapy Group

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Liver steatosis in chronic hepatitis C: a morphological sign suggesting infection with HCV genotype 3.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Expression of liver steatosis in hepatitis C virus infection and pattern of response to alpha-interferon

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Detection of three types of hepatitis C virus in blood donors: investigation of type-specific differences in serologic reactivity and rate of alanine aminotransferase abnormalities

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Patterns of serological markers in transfusion-transmitted hepatitis C virus infection using second-generation HCV assays

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Comparison of plasma virus loads among individuals infected with hepatitis C virus (HCV) genotypes 1, 2, and 3 by quantiplex HCV RNA assay versions 1 and 2, Roche Monitor assay, and an in-house limiting dilution method

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Genotype dependence of hepatitis C virus load measurement in commercially available quantitative assays.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus resistance to antiviral therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Therapy of hepatitis C: overview

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (I

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Treatment of acute hepatitis C with interferon alfa-2b

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Immunity in chimpanzees chronically infected with hepatitis C virus: role of minor quasispecies in reinfection

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Molecular epidemiology of an outbreak of infection with hepatitis C virus in recipients of anti-D immunoglobulin

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Evolution in the hypervariable region of hepatitis C virus in infants after vertical transmission

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Evolution of hepatitis C virus quasispecies in mothers and infants infected through mother-to-infant transmission

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Acute hepatitis C virus structural gene sequences as predictors of persistent viremia: hypervariable region 1 as a decoy

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Multicycle infection of hepatitis C virus in cell culture and inhibition by alpha and beta interferons

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Does the hepatitis C virus replicate in cells of the hematopoietic lineage?

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Clinical implications of viral quasispecies heterogeneity in chronic hepatitis C.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Relation of disease activity during chronic hepatitis C infection to complexity of hypervariable region 1 quasispecies

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C viral quasispecies and liver damage in patients with chronic hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Relationship of the genomic complexity of hepatitis C virus with liver disease severity and response to interferon in patients with chronic HCV genotype 1b infection [correction of interferon].

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Sequence analysis of hypervariable region of hepatitis C virus (HCV) associated with immune complex in patients with chronic HCV infection

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Early changes in hepatitis C viral quasispecies during interferon therapy predict the therapeutic outcome

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Hepatitis C virus kinetics during and immediately after liver transplantation.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2802%2900065-X

7 January 2021

10.1016/S1089-3261(02)00065-X

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12691458