Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition. (Q35108834)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24587280%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24587280%20AND%20SRC:MED&resulttype=core&format=json

Jose Luis López-Sendón Moreno

9 March 2020

main subject

alpha,alpha-trehalose

0 references

Huntington's disease

0 references

author

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24587280%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

author name string

Maria Angeles Fernandez-Estevez

1

1 reference

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9 March 2020

Maria Jose Casarejos

2

1 reference

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9 March 2020

Juan Garcia Caldentey

4

1 reference

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9 March 2020

Carolina Ruiz

5

1 reference

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9 March 2020

Ana Gomez

6

1 reference

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9 March 2020

Juan Perucho

7

1 reference

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9 March 2020

Justo García de Yebenes

8

1 reference

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9 March 2020

Maria Angeles Mena

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24587280%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

language of work or name

English

0 references

publication date

25 February 2014

1 reference

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9 March 2020

1 reference

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9 March 2020

volume

9

1 reference

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9 March 2020

issue

2

1 reference

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9 March 2020

page(s)

e90202

1 reference

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Creative Commons Attribution 4.0 International

9 March 2020

copyright license

start time

25 February 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells

9 July 2018

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Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

9 July 2018

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Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments

9 July 2018

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Regulation of the endothelial cell cycle by the ubiquitin-proteasome system.

9 July 2018

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Effect of trehalose on protein structure

9 July 2018

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9 July 2018

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Mitochondria and ubiquitin-proteasomal system interplay: relevance to Parkinson's disease

9 July 2018

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9 July 2018

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Proteasome modulates mitochondrial function during cellular senescence

9 July 2018

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

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Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals

9 July 2018

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Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

9 July 2018

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Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

9 July 2018

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Lessons from animal models of Huntington's disease

9 July 2018

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Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients

9 July 2018

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9 July 2018

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

9 July 2018

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

9 July 2018

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Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

9 July 2018

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Emerging roles of caspase-3 in apoptosis

9 July 2018

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Influence of molecular and chemical chaperones on protein folding

9 July 2018

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The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

9 July 2018

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

9 July 2018

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Skin fibroblasts in Huntington disease.

9 July 2018

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Uncoating ATPase is a member of the 70 kilodalton family of stress proteins.

9 July 2018

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Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

9 July 2018

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Glial dysfunction in parkin null mice: effects of aging.

27 September 2018

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Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

27 September 2018

1 reference

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Oxidative stress in skin fibroblasts cultures of patients with Huntington's disease.

27 September 2018

1 reference

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Differential effects of l-DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal-enriched cultures from parkin knockout and wild-type mice

27 September 2018

1 reference

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Generalized brain and skin proteasome inhibition in Huntington's disease

27 September 2018

1 reference

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Selective and persistent activation of extracellular signal-regulated protein kinase by nitric oxide in glial cells induces neuronal degeneration in glutathione-depleted midbrain cultures

27 September 2018

1 reference

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Autophagy regulates the processing of amino terminal huntingtin fragments

27 September 2018

1 reference

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Glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways

27 September 2018

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Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells

27 September 2018

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Downregulation of the ERK 1 and 2 mitogen activated protein kinases using antisense oligonucleotides inhibits proliferation of porcine vascular smooth muscle cells

27 September 2018

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Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

27 September 2018

1 reference

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Complex I defect in muscle from patients with Huntington's disease.

27 September 2018

1 reference

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Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24587280

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0090202

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24587280%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24587280%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24587280%20AND%20SRC:MED&resulttype=core&format=json