Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK (Q35116609)

6 August 2017

title

Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK (English)

1 reference

6 August 2017

Siyuan Dai

1

1 reference

6 August 2017

Zijian Tang

2

1 reference

6 August 2017

Junyue Cao

3

1 reference

6 August 2017

Wei Zhou

4

1 reference

6 August 2017

Huawen Li

5

1 reference

6 August 2017

Stephen Sampson

6

1 reference

6 August 2017

Chengkai Dai

7

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6 August 2017

language of work or name

English

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publication date

25 November 2014

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6 August 2017

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6 August 2017

volume

34

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6 August 2017

issue

3

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6 August 2017

page(s)

275-293

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Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis.

6 August 2017

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

9 July 2018

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9 July 2018

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mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease

9 July 2018

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9 July 2018

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Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome

9 July 2018

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9 July 2018

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AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

9 July 2018

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Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis

9 July 2018

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Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis

9 July 2018

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9 July 2018

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9 July 2018

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In vivo analysis of heat-shock-protein-70 induction following pulsed laser irradiation in a transgenic reporter mouse

9 July 2018

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Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

9 July 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

9 July 2018

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

9 July 2018

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Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding

9 July 2018

1 reference

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Heat shock response modulators as therapeutic tools for diseases of protein conformation

9 July 2018

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

9 July 2018

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

9 July 2018

1 reference

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Metformin and reduced risk of cancer in diabetic patients

9 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339117

Modulation of neurodegeneration by molecular chaperones

9 July 2018

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Ubiquitin: structures, functions, mechanisms

9 July 2018

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TSC2 mediates cellular energy response to control cell growth and survival

9 July 2018

1 reference

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Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

9 July 2018

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Role of AMP-activated protein kinase in mechanism of metformin action

9 July 2018

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A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

9 July 2018

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Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

9 July 2018

1 reference

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

9 July 2018

1 reference

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HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice

9 July 2018

1 reference

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Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

9 July 2018

1 reference

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5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

9 July 2018

1 reference

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9 July 2018

The heat-shock response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339117

The role of heat-shock proteins as molecular chaperones

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339117

Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration

9 July 2018

1 reference

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Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.

27 September 2018

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27 September 2018

1 reference

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27 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339117

Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors

27 September 2018

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12 December 2020

Increasing the dynamic range of in situ PLA

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12 December 2020

The effect of intravenous metformin on glucose metabolism during hyperglycaemia in type 2 diabetes

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12 December 2020

Role of the AMP-activated protein kinase in the cellular stress response

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12 December 2020

Identifiers

DOI

10.15252/EMBJ.201489062

1 reference

6 August 2017

1 reference

6 August 2017

1 reference