Renewing the debate over the p53 apoptotic response (Q35116649)

6 August 2017

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title

Renewing the debate over the p53 apoptotic response (English)

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6 August 2017

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Weber JD

1

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PubMed ID

12719717

6 August 2017

Zambetti GP

series ordinal

2

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6 August 2017

1 April 2003

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Cell Death & Differentiation

6 August 2017

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6 August 2017

10

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6 August 2017

4

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6 August 2017

409-412

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401226

6 August 2017

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cites work

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PUMA, a novel proapoptotic gene, is induced by p53

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The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

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A transactivation-deficient mouse model provides insights into Trp53 regulation and function

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Wild-type p53 is a cell cycle checkpoint determinant following irradiation

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

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p53 is required for radiation-induced apoptosis in mouse thymocytes

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Thymocyte apoptosis induced by p53-dependent and independent pathways.

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Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein

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p53 and E2F-1 cooperate to mediate apoptosis

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

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Wild-type p53 negatively regulates the expression of a microtubule-associated protein

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Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction.

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest

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Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies

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Nucleolar Arf sequesters Mdm2 and activates p53

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Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

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ASPP proteins specifically stimulate the apoptotic function of p53

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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

21 January 2018

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

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Dissecting p53 tumor suppressor functions in vivo

21 January 2018

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

21 January 2018

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401226

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.CDD.4401226

1 reference

6 August 2017

1 reference

PubMed ID

12719717