Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations. (Q35119689)

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1 February 2020

title

Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations (English)

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1 February 2020

8

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author name string

Kirk Cunningham

1

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1 February 2020

Yutaka Uchida

2

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1 February 2020

Erin O'Donnell

3

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1 February 2020

Estefania Claudio

4

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1 February 2020

Wenling Li

5

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1 February 2020

Kosha Soneji

6

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1 February 2020

Hongshan Wang

7

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1 February 2020

Ulrich Siebenlist

9

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publication date

19 May 2011

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1 February 2020

published in

Human Molecular Genetics

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1 February 2020

volume

20

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issue

16

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page(s)

3198-3206

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Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology

1 February 2020

cites work

1 reference

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A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.

9 July 2018

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Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3

9 July 2018

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Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

9 July 2018

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Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling

9 July 2018

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Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development

9 July 2018

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Recent insights into cerebral cavernous malformations: the molecular genetics of CCM.

9 July 2018

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Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype

9 July 2018

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Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction

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Cerebral cavernous malformations: somatic mutations in vascular endothelial cells

9 July 2018

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Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations

9 July 2018

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The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

9 July 2018

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Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

9 July 2018

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Angiogenesis after cerebral ischemia

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A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells

9 July 2018

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Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

9 July 2018

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Notch signaling is essential for ventricular chamber development

9 July 2018

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Genetics of cavernous angiomas

9 July 2018

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New vessel formation in the central nervous system during tumor growth, vascular malformations, and Moyamoya

9 July 2018

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Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback.

9 July 2018

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Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations.

9 July 2018

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Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.

9 July 2018

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Mutations within the MGC4607 gene cause cerebral cavernous malformations

9 July 2018

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9 July 2018

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Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations

9 July 2018

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Notch signaling is required for arterial-venous differentiation during embryonic vascular development.

9 July 2018

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Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations

9 July 2018

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9 July 2018

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9 July 2018

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Differential angiogenesis function of CCM2 and CCM3 in cerebral cavernous malformations

9 July 2018

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Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations.

27 September 2018

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Biallelic somatic and germ line CCM1 truncating mutations in a cerebral cavernous malformation lesion.

27 September 2018

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Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.

27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

Identifiers

DOI

10.1093/HMG/DDR225

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1 February 2020

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1 February 2020

PubMed publication ID

21596842

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