Viral vectors for gene delivery to the nervous system (Q35120134)

6 August 2017

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title

Viral vectors for gene delivery to the nervous system (English)

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6 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12728263

30 December 2023

genetic vector

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12728263

nervous system physiological phenomenon

30 December 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12728263

30 December 2023

author

Xandra O. Breakefield

series ordinal

2

object named as

Xandra O Breakefield

1 reference

6 August 2017

Beverly L. Davidson

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12728263

30 December 2023

language of work or name

English

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publication date

1 May 2003

1 reference

full work available at URL

6 August 2017

https://www.nature.com/articles/nrn1104.pdf

file format

Portable Document Format

1 reference

https://www.nature.com/articles/nrn1104

30 December 2023

1 reference

Nature Reviews Neuroscience

30 December 2023

published in

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6 August 2017

4

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6 August 2017

5

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6 August 2017

353-364

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https://scigraph.springernature.com/pub.10.1038/nrn1104

6 August 2017

0 references

cites work

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Selective and rapid uptake of adeno-associated virus type 2 in brain

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Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity

31 March 2020

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Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size.

31 March 2020

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Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model

31 March 2020

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Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis

31 March 2020

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Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

31 March 2020

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Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors

31 March 2020

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Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver

31 March 2020

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Transfer of a foreign gene into the brain using adenovirus vectors

31 March 2020

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A model system for in vivo gene transfer into the central nervous system using an adenoviral vector.

31 March 2020

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(Re-)Engineering tumor cell-selective replicating adenoviruses: a step in the right direction toward systemic therapy for metastatic disease

31 March 2020

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Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10.

31 March 2020

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Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B.

31 March 2020

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Generation and growth of gutted adenoviral vectors

31 March 2020

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Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

31 March 2020

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High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity

31 March 2020

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Herpes simplex virus as a transneuronal tracer

31 March 2020

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The herpes simplex virus 2 kb latency associated transcript (LAT) leader sequence allows efficient expression of downstream proteins which is enhanced in neuronal cells: possible function of LAT ORFs

31 March 2020

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The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

31 March 2020

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An infectious transfer and expression system for genomic DNA loci in human and mouse cells

31 March 2020

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HSV-1 amplicon vectors--simplicity and versatility

31 March 2020

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Potential of gene therapy for brain tumors

31 March 2020

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Lineage-independent determination of cell type in the embryonic mouse retina

31 March 2020

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A recombinant retrovirus encoding alkaline phosphatase confirms clonal boundary assignment in lineage analysis of murine retina

31 March 2020

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Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors

31 March 2020

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HIV-1 integration in the human genome favors active genes and local hotspots

31 March 2020

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Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates

31 March 2020

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Inhibiting AIDS in the central nervous system: gene delivery to protect neurons from HIV.

31 March 2020

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In vitro-packaged SV40 pseudovirions as highly efficient vectors for gene transfer.

31 March 2020

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Cytokine production in motor neurons by poliovirus replicon vector gene delivery

31 March 2020

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Repetitive intrathecal injections of poliovirus replicons result in gene expression in neurons of the central nervous system without pathogenesis

31 March 2020

1 reference

Alphaviral vectors for gene transfer into neurons

31 March 2020

1 reference

Exploiting circuit-specific spread of pseudorabies virus in the central nervous system: insights to pathogenesis and circuit tracers

31 March 2020

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Peptide-Retargeted Adenovirus Encoding a Tissue Inhibitor of Metalloproteinase-1 Decreases Restenosis after Intravascular Gene Transfer

31 March 2020

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Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype

31 March 2020

1 reference

Tropism-modified adenoviral and adeno-associated viral vectors for gene therapy

31 March 2020

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31 March 2020

1 reference

Recombinant human adenovirus: targeting to the human transferrin receptor improves gene transfer to brain microcapillary endothelium

31 March 2020

1 reference

Adeno-associated virus capsids displaying immunoglobulin-binding domains permit antibody-mediated vector retargeting to specific cell surface receptors

31 March 2020

1 reference

Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids

31 March 2020

1 reference

Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery

31 March 2020

1 reference

In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins

31 March 2020

1 reference

Targeted transduction patterns in the mouse brain by lentivirus vectors pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV envelope proteins

31 March 2020

1 reference

Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors

31 March 2020

1 reference

Targeted retrograde gene delivery for neuronal protection

31 March 2020

1 reference

Neurotropism and retrograde axonal transport of a canine adenoviral vector: a tool for targeting key structures undergoing neurodegenerative processes.

31 March 2020

1 reference

Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach

31 March 2020

1 reference

Osmotic blood-brain barrier modification: monoclonal antibody, albumin, and methotrexate delivery to cerebrospinal fluid and brain

31 March 2020

1 reference

Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms.

31 March 2020

1 reference

Widespread gene delivery and structure-specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector

31 March 2020

1 reference

Elimination of lysosomal storage in brains of MPS VII mice treated by intrathecal administration of an adeno-associated virus vector

31 March 2020

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Brain engraftment of autologous macrophages transduced with a lentiviral flap vector: an approach to complement brain dysfunctions

31 March 2020

1 reference

Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression

31 March 2020

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The subventricular zone: source of neuronal precursors for brain repair.

31 March 2020

1 reference

The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue

31 March 2020

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Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas

31 March 2020

1 reference

Mammalian neural stem cells

31 March 2020

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Stem cells in the central nervous system

31 March 2020

1 reference

Viral-mediated gene transfer to mouse primary neural progenitor cells.

31 March 2020

1 reference

A single adenovirus vector mediates doxycycline-controlled expression of tyrosine hydroxylase in brain grafts of human neural progenitors.

31 March 2020

1 reference

Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging

31 March 2020

1 reference

Neural precursor cells for delivery of replication-conditional HSV-1 vectors to intracerebral gliomas

31 March 2020

1 reference

Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain

31 March 2020

1 reference

Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins.

31 March 2020

1 reference

Improved version of the red fluorescent protein (drFP583/DsRed/RFP).

31 March 2020

1 reference

Humoral immune responses to adenovirus vectors in the brain

31 March 2020

1 reference

Reporter gene transfer induces apoptosis in primary cortical neurons.

31 March 2020

1 reference

Green fluorescent protein imaging of tumour growth, metastasis, and angiogenesis in mouse models

31 March 2020

1 reference

Brain-specific expression of an exogenous gene after i.v. administration

31 March 2020

1 reference

Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice

31 March 2020

1 reference

In vivo magnetic resonance imaging of transgene expression.

31 March 2020

1 reference

Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus

31 March 2020

1 reference

In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus

31 March 2020

1 reference

Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument

31 March 2020

1 reference

Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells

31 March 2020

1 reference

Intact microtubules support adenovirus and herpes simplex virus infections

31 March 2020

1 reference

Mapping the in vivo distribution of herpes simplex virions

31 March 2020

1 reference

Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line

31 March 2020

1 reference

Generation and migration of cells in the developing striatum

31 March 2020

1 reference

Herpes simplex virus type 1/adeno-associated virus rep(+) hybrid amplicon vector improves the stability of transgene expression in human cells by site-specific integration

31 March 2020

1 reference

Herpes simplex virus type 1/adeno-associated virus hybrid vectors mediate site-specific integration at the adeno-associated virus preintegration site, AAVS1, on human chromosome 19.

31 March 2020

1 reference

Second generation adeno-associated virus type 2-based gene therapy systems with the potential for preferential integration into AAVS1.

31 March 2020

1 reference

Site-specific integration by adeno-associated virus

31 March 2020

1 reference

Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system

31 March 2020

1 reference

Mammalian genomes contain active recombinase recognition sites

31 March 2020

1 reference

Site-specific genomic integration produces therapeutic Factor IX levels in mice

31 March 2020

1 reference

The potential of extrachromosomal replicating vectors for gene therapy

31 March 2020

1 reference

Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brain.

31 March 2020

1 reference

Adenoviral-mediated, high-level, cell-specific transgene expression: a SYN1-WPRE cassette mediates increased transgene expression with no loss of neuron specificity

31 March 2020

1 reference

Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors

31 March 2020

1 reference

A tyrosine hydroxylase-neurofilament chimeric promoter enhances long-term expression in rat forebrain neurons from helper virus-free HSV-1 vectors

31 March 2020

1 reference

Rescue of neurodegeneration in Niemann-Pick C mice by a prion-promoter-driven Npc1 cDNA transgene.

31 March 2020

1 reference

Setting the boundaries of chromatin domains and nuclear organization

31 March 2020

1 reference

Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors

31 March 2020

1 reference

Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector

31 March 2020

1 reference

Drug inducible transgene expression in brain using a herpes simplex virus vector

31 March 2020

1 reference

Modified herpes simplex virus delivery of enhanced GFP into the central nervous system.

31 March 2020

1 reference

In vivo transduction of central neurons using recombinant Sindbis virus: Golgi-like labeling of dendrites and axons with membrane-targeted fluorescent proteins

31 March 2020

1 reference

Construction of hybrid proteins that migrate retrogradely and transynaptically into the central nervous system

31 March 2020

1 reference

Visualizing postendocytic traffic of synaptic vesicles at hippocampal synapses

31 March 2020

1 reference

Assembly of presynaptic active zones from cytoplasmic transport packets

31 March 2020

1 reference

Visualization of IP(3) dynamics reveals a novel AMPA receptor-triggered IP(3) production pathway mediated by voltage-dependent Ca(2+) influx in Purkinje cells

31 March 2020

1 reference

Multiple mechanisms for the potentiation of AMPA receptor-mediated transmission by alpha-Ca2+/calmodulin-dependent protein kinase II.

31 March 2020

1 reference

Activation-dependent changes in receptor distribution and dendritic morphology in hippocampal neurons expressing P2X2-green fluorescent protein receptors

31 March 2020

1 reference

NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase

31 March 2020

1 reference

Tracing functionally identified neurones in a multisynaptic pathway in the hamster and rat using herpes simplex virus expressing green fluorescent protein

31 March 2020

1 reference

Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase

31 March 2020

1 reference

Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse

31 March 2020

1 reference

Z/AP, a double reporter for cre-mediated recombination.

31 March 2020

1 reference

Adeno-associated virus effectively mediates conditional gene modification in the brain

31 March 2020

1 reference

Characterization of transgene expression and Cre recombinase activity in a panel of Thy-1 promoter-Cre transgenic mice.

31 March 2020

1 reference

Functional expression of Cre recombinase in sub-regions of mouse CNS and retina

31 March 2020

1 reference

Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer

31 March 2020

1 reference

Targeted transgene integration into transgenic mouse fibroblasts carrying the full-length human AAVS1 locus mediated by HSV/AAV rep(+) hybrid amplicon vector.

31 March 2020

1 reference

Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells

31 March 2020

1 reference

Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutamine segment

31 March 2020

1 reference

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

31 March 2020

1 reference

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

31 March 2020

1 reference

Neuroprotective gene therapy against acute neurological insults

31 March 2020

1 reference

Functional regeneration of chronically injured sensory afferents into adult spinal cord after neurotrophin gene therapy.

31 March 2020

1 reference

Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair

31 March 2020

1 reference

Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury

31 March 2020

1 reference

Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord

31 March 2020

1 reference

Long-term gene therapy in the CNS: reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin.

31 March 2020

1 reference

Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation

31 March 2020

1 reference

Dopaminergic neurons protected from degeneration by GDNF gene therapy

31 March 2020

1 reference

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

31 March 2020

1 reference

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

31 March 2020

1 reference

Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer

31 March 2020

1 reference

Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat

31 March 2020

1 reference

31 March 2020

Gene therapy in the CNS.

1 reference

Antisense gene therapy for neurodegenerative disease?

31 March 2020

1 reference

Ribozyme-mediated trans-splicing of a trinucleotide repeat.

31 March 2020

1 reference

Analysis of gene function in somatic mammalian cells using small interfering RNAs

31 March 2020

1 reference

Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference

31 March 2020

1 reference

siRNA-mediated gene silencing in vitro and in vivo.

31 March 2020

1 reference

Retrovirus-delivered siRNA

31 March 2020

1 reference

Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.

31 March 2020

1 reference

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

31 March 2020

1 reference

Viral-mediated delivery of the late-infantile neuronal ceroid lipofuscinosis gene, TPP-I to the mouse central nervous system

31 March 2020

1 reference

In vivo gene therapy of metachromatic leukodystrophy by lentiviral vectors: correction of neuropathology and protection against learning impairments in affected mice

31 March 2020

1 reference

The HIV Tat protein transduction domain improves the biodistribution of beta-glucuronidase expressed from recombinant viral vectors.

31 March 2020

1 reference

Guided genes for tumor warfare

31 March 2020

1 reference

Selectively replicating viral vectors

31 March 2020

1 reference

Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion

31 March 2020

1 reference

Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors.

31 March 2020

1 reference

Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus

31 March 2020

1 reference

Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons.

31 March 2020

1 reference

Mammalian artificial chromosomes as vectors: progress and prospects

31 March 2020

1 reference

Design and packaging of adeno-associated virus gene targeting vectors

31 March 2020

1 reference

Viral immune evasion: a masterpiece of evolution

31 March 2020

1 reference

Viruses as gene delivery vectors: application to gene function, target validation, and assay development

31 March 2020

1 reference

Stepwise dismantling of adenovirus 2 during entry into cells

31 March 2020

1 reference

Recombinant herpes simplex virus type 1 engineered for targeted binding to erythropoietin receptor-bearing cells.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

44

58

5738

CR Miller

1998

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30 December 2023

83

60

4953

CH Tung

2000

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30 December 2023

105

61

6987

N Shimizu

2001

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30 December 2023

166

56

5423

JS Yu

1996

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30 December 2023

Identifiers

DOI

10.1038/NRN1104

1 reference

6 August 2017

1 reference