ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications (Q35129038)

6 August 2017

1 reference

title

ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications (English)

1 reference

6 August 2017

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Yingmei Zhang

1

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6 August 2017

Jun Ren

series ordinal

2

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6 August 2017

publication date

12 June 2011

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Pharmacology & Therapeutics

6 August 2017

published in

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6 August 2017

volume

132

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6 August 2017

issue

1

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6 August 2017

page(s)

86-95

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mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism

6 August 2017

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Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

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Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells

13 July 2018

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Involvement of AMPK in alcohol dehydrogenase accentuated myocardial dysfunction following acute ethanol challenge in mice

13 July 2018

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Mitochondrial aldehyde dehydrogenase and cardiac diseases

13 July 2018

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Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases

13 July 2018

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13 July 2018

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13 July 2018

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Alcohol dehydrogenase accentuates ethanol-induced myocardial dysfunction and mitochondrial damage in mice: role of mitochondrial death pathway

13 July 2018

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Association of ALDH2 genotypes with periodontitis progression

13 July 2018

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13 July 2018

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Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?

13 July 2018

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Alcoholism and alcohol abstinence: N-acetylcysteine to improve energy expenditure, myocardial oxidative stress, and energy metabolism in alcoholic heart disease

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex

13 July 2018

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13 July 2018

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Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress

13 July 2018

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Alcohol abuse and heart failure

13 July 2018

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Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction.

13 July 2018

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Autophagy, redox signaling, and ventricular remodeling

13 July 2018

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Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer

13 July 2018

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Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations

13 July 2018

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Mechanisms of alcoholic heart disease

13 July 2018

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13 July 2018

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13 July 2018

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Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

13 July 2018

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Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males

13 July 2018

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Alcohol consumption and heart failure: a systematic review

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology

13 July 2018

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Workshop on Alcohol Use and Health Disparities 2002: a call to arms

13 July 2018

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MAP kinase signaling in diverse effects of ethanol

13 July 2018

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Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase

13 July 2018

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13 July 2018

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Regulation of cardiac myocyte cell death

13 July 2018

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Effect of alcohol on lipids and lipoproteins in relation to atherosclerosis

13 July 2018

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13 July 2018

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CYP2E1-dependent toxicity and oxidative stress in HepG2 cells

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Role of acetaldehyde in the induction of heart left ventricular atrial natriuretic peptide gene expression in rats

13 July 2018

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Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians

13 July 2018

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A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy

13 July 2018

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An A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase (ALDH2): effects of the sequence variant on transcription factor binding and promoter strength

13 July 2018

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Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress

13 July 2018

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The effects of alcohol on the heart.

13 July 2018

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Acetaldehyde inhibits current through voltage-dependent calcium channels

13 July 2018

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Determinations of ethanol, acetaldehyde and acetate in blood and urine during alcohol oxidation in man.

13 July 2018

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Effects of acetaldehyde on the automaticity of the guinea pig sinus node

13 July 2018

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Effects of acetaldehyde on membrane potentials of sinus node pacemaker fibers

13 July 2018

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13 July 2018

Alcohol and fibrogenesis

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Alcohol consumption and carotid atherosclerosis in China: the Cardiovascular Risk Survey

13 July 2018

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Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice.

27 September 2018

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Association between aldehyde dehydrogenase 2 genetic polymorphism and serum lipids or lipoproteins: a meta-analysis of seven East Asian populations

27 September 2018

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Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide: a preliminary observation in the Japanese male population

27 September 2018

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Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor

27 September 2018

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Use of acetaldehyde and methanol as markers of alcohol abuse and their measurement

27 September 2018

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Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver

27 September 2018

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Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Chronic alcohol feeding impairs mTOR(Ser 2448) phosphorylation in rat hearts

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Acetaldehyde, polymorphisms and the cardiovascular system.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Cardiac overexpression of metallothionein rescues chronic alcohol intake-induced cardiomyocyte dysfunction: role of Akt, mammalian target of rapamycin and ribosomal p70s6 kinase.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

ALDH2 polymorphisms and bone mineral density in an elderly Japanese population

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

A murine model of alcoholic cardiomyopathy: a role for zinc and metallothionein in fibrosis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Long-term alcohol consumption and the risk of atrial fibrillation in the Framingham Study

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Association of ALDH(2) genotypes and alcohol consumption with periodontitis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Malondialdehyde inhibits cardiac contractile function in ventricular myocytes via a p38 mitogen-activated protein kinase-dependent mechanism

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Cardiac-specific overexpression of catalase rescues ventricular myocytes from ethanol-induced cardiac contractile defect.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Short-term acetaldehyde exposure depresses ventricular myocyte contraction: role of cytochrome P450 oxidase, xanthine oxidase, and lipid peroxidation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Alcohol metabolism: role in toxicity and carcinogenesis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Influence of gender on ethanol-induced ventricular myocyte contractile depression in transgenic mice with cardiac overexpression of alcohol dehydrogenase.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

The influence of gender, diabetes, and acetaldehyde on the intrinsic contractile properties of isolated rat myocardium

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Influence of prenatal ethanol exposure on vascular contractile response in rat thoracic aorta

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Combined calcium carbimide and ethanol treatment induces high blood acetaldehyde levels, myocardial apoptosis and altered expression of apoptosis-regulating genes in rat.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Influence of hypertension on acetaldehyde-induced vasorelaxation in rat thoracic aorta

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: preferential localisation in the sarcolemmal and subsarcolemmal region.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Cytochrome P450 2E1 (CYP2E1)-dependent production of a 37-kDa acetaldehyde-protein adduct in the rat liver

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Ethanol-induced inhibition of ventricular protein synthesis in vivo and the possible role of acetaldehyde

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

Effects of Variation at the ALDH2 Locus on Alcohol Metabolism, Sensitivity, Consumption, and Dependence in Europeans

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144032

8 December 2018

Alcoholic cardiomyopathy

1 reference

12 December 2020

Effects of lifelong ethanol consumption on the ultrastructure and lipopigmentation of rat heart

1 reference

12 December 2020

Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese

1 reference

12 December 2020

Determinants of Blood Acetaldehyde Level during Ethanol Oxidation in Chronic Alcoholics

1 reference

12 December 2020

Alcohol and the myocardium

1 reference

12 December 2020

Alcohol and the heart

1 reference

12 December 2020

Association With Serum Gamma-Glutamyltransferase Levels and Alcohol Consumption on Stroke and Coronary Artery Disease

1 reference

12 December 2020

Potentiated sympathetic and hemodynamic responses to alcohol in hypertensive vs. normotensive individuals

1 reference

12 December 2020

Acetaldehyde depresses myocardial contraction and cardiac myocyte shortening in spontaneously hypertensive rats: role of intracellular Ca2+

1 reference

12 December 2020

Oxidative stress and alcoholic liver disease

1 reference

12 December 2020

Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models

1 reference

12 December 2020

[The positive chronotropic effects of salsolinol on the isolated rat heart]

1 reference

12 December 2020

The ALDH2 genotype, alcohol intake, and liver-function biomarkers among Japanese male workers

1 reference

12 December 2020

A report of unusually high blood ethanol and acetaldehyde levels in two surviving patients

1 reference

12 December 2020

Effects of acute acetaldehyde, chronic ethanol, and pargyline treatment on agonist responses of the rat aorta

1 reference

12 December 2020

Biphasic changes in cardiac excitation-contraction coupling early in chronic alcohol exposure

1 reference

12 December 2020

Severe hypertriglyceridemia influenced by alcohol (SHIBA)

1 reference

12 December 2020

Effects of acetaldehyde on the isolated papillary muscle of diabetic rats

1 reference

12 December 2020

Ethanol and acetaldehyde concentrations in the rat foeto-maternal system after an acute ethanol administration given to the mother

1 reference

12 December 2020

Acetaldehyde depresses shortening and intracellular Ca2+ transients in adult rat ventricular myocytes

1 reference

12 December 2020

Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele

1 reference

12 December 2020

Evidence of apoptosis in alcoholic cardiomyopathy

1 reference

12 December 2020

Effects of abstinence on alcoholic heart muscle disease

1 reference

12 December 2020

10.1016/J.PHARMTHERA.2011.05.008

Identifiers

DOI

1 reference

6 August 2017

1 reference

6 August 2017

1 reference