Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol (Q35129073)

25646431

6 August 2017

title

Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol (English)

1 reference

6 August 2017

6

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1 June 2020

author name string

Adele Stewart

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25646431%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Biswanath Maity

2

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1 June 2020

Simon P Anderegg

3

1 reference

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1 June 2020

Chantal Allamargot

4

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1 June 2020

Jianqi Yang

5

1 reference

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1 June 2020

language of work or name

English

0 references

publication date

2 February 2015

1 reference

25646431

Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

published in

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1 June 2020

volume

112

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1 June 2020

issue

7

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1 June 2020

page(s)

E786-95

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Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals

1 June 2020

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Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.

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CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis

13 July 2018

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Regulator of G protein signaling 6 is a novel suppressor of breast tumor initiation and progression

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A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence

13 July 2018

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13 July 2018

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Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner

13 July 2018

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The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis

13 July 2018

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Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins

13 July 2018

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Oxidative stress and redox signaling mechanisms of alcoholic liver disease: updated experimental and clinical evidence

13 July 2018

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Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling.

13 July 2018

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Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice

13 July 2018

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Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems

13 July 2018

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NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair

13 July 2018

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Role of the serotonergic system in alcohol dependence: from animal models to clinics

13 July 2018

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Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity.

13 July 2018

1 reference

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RGS6/Gβ5 Complex Accelerates I KACh Gating Kinetics in Atrial Myocytes and Modulates Parasympathetic Regulation of Heart Rate

13 July 2018

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Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with Doxorubicin chemotherapy

13 July 2018

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RGS6, a modulator of parasympathetic activation in heart.

13 July 2018

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Medications acting on the dopaminergic system in the treatment of alcoholic patients

13 July 2018

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Safety and efficacy of baclofen in the treatment of alcohol-dependent patients

13 July 2018

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Intramyocardial fibroblast myocyte communication

13 July 2018

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The neurobiology, clinical efficacy and safety of acamprosate in the treatment of alcohol dependence

13 July 2018

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Role of the GABA(B) receptor in alcohol-seeking and drinking behavior

13 July 2018

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Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J mice

13 July 2018

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Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area

13 July 2018

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Ethanol enhances GABAergic transmission onto dopamine neurons in the ventral tegmental area of the rat.

13 July 2018

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Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gbeta5 complexes in brain

13 July 2018

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13 July 2018

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13 July 2018

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R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol?

13 July 2018

1 reference

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D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

Essential role for RGS9 in opiate action

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

The R7 subfamily of RGS proteins assists tachyphylaxis and acute tolerance at mu-opioid receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

RGS9 modulates dopamine signaling in the basal ganglia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

13 July 2018

1 reference

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Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells

13 July 2018

1 reference

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Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways

13 July 2018

1 reference

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Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

RGS proteins and signaling by heterotrimeric G proteins

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

Cellular and molecular neuroscience of alcoholism

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.

13 July 2018

1 reference

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Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

G-protein inactivator RGS6 mediates myocardial cell apoptosis and cardiomyopathy caused by doxorubicin.

13 July 2018

1 reference

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Serotonin receptor, SERT mRNA and correlations with symptoms in males with alcohol dependence and suicide

27 September 2018

1 reference

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RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease.

27 September 2018

1 reference

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RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.

27 September 2018

1 reference

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Differential modulation by nicotine of substantia nigra versus ventral tegmental area dopamine neurons

27 September 2018

1 reference

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Ethanol-induced conditioned place preference is expressed through a ventral tegmental area dependent mechanism

27 September 2018

1 reference

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Rapid suppression of alcohol withdrawal syndrome by baclofen.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

Ethanol directly excites dopaminergic ventral tegmental area reward neurons.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

Gamma-vinyl GABA inhibits methamphetamine, heroin, or ethanol-induced increases in nucleus accumbens dopamine

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343156

R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25646431

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1418795112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25646431%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

0 references

1 reference

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1 June 2020

25646431

1 reference

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