Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure (Q35130547)

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25 January 2020

title

Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure (English)

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25 January 2020

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1

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C P Reynolds

5

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Min H Kang

9

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author name string

Kyunghwa Hwang

2

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Hardeep Singh

3

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Dong Wang

4

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Robert W Curley

6

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Simon C Williams

7

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Barry J Maurer

8

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language of work or name

English

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publication date

1 July 2011

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British Journal of Pharmacology

25 January 2020

published in

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volume

163

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issue

6

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page(s)

1263-1275

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Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP‐glucuronosyltransferases

25 January 2020

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Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.

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N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes.

28 July 2018

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Decrease in drug accumulation and in tumour aggressiveness marker expression in a fenretinide-induced resistant ovarian tumour cell line

28 July 2018

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Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells

28 July 2018

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Effects of cytochrome P-450 inhibitors on the in vivo metabolism of all-trans-retinoic acid in rats

28 July 2018

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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12 December 2020

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Identifiers

DOI

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25 January 2020

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25 January 2020

PubMed publication ID

21391977

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