Adaptive and innate immune responses to gene transfer vectors: role of cytokines and chemokines in vector function (Q35131239)

6 August 2017

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title

Adaptive and innate immune responses to gene transfer vectors: role of cytokines and chemokines in vector function (English)

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6 August 2017

Chen D

1

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6 August 2017

Murphy B

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2

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6 August 2017

Sung R

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3

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6 August 2017

Bromberg JS

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4

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6 August 2017

1 June 2003

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6 August 2017

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6 August 2017

10

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6 August 2017

11

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6 August 2017

991-998

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302031

6 August 2017

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DNA from both high-capacity and first-generation adenoviral vectors remains intact in skeletal muscle.

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CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

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The role of CpG motifs in immunostimulation and gene therapy

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CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

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Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

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Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

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Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors.

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Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

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The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

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21 January 2018

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TRAF6 is a signal transducer for interleukin-1

21 January 2018

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ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

21 January 2018

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The double-stranded RNA-dependent protein kinase PKR: structure and function

21 January 2018

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PKR; a sentinel kinase for cellular stress

21 January 2018

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The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors

21 January 2018

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The DNA-dependent protein kinase

21 January 2018

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Interferon regulatory factor-3 is an in vivo target of DNA-PK.

21 January 2018

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A role for DNA-PK in retroviral DNA integration

21 January 2018

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Adenovirus E4 34k and E4 11k inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinase

21 January 2018

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Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression

21 January 2018

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Chemokines: a new classification system and their role in immunity

21 January 2018

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Chemokines as regulators of T cell differentiation.

21 January 2018

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Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses.

21 January 2018

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Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors

21 January 2018

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Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors

21 January 2018

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Stimulatory and inhibitory action of cytokines on the regulation of hCMV-IE promoter activity in human endothelial cells

21 January 2018

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Interferon-gamma inhibits transgene expression driven by SV40 or CMV promoters but augments expression driven by the mammalian MHC I promoter

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Interferons inhibit onset of murine cytomegalovirus immediate-early gene transcription.

21 January 2018

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Interferon gamma regulates acute and latent murine cytomegalovirus infection and chronic disease of the great vessels

21 January 2018

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Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Systemic production of IL-12 by naked DNA mediated gene transfer: toxicity and attenuation of transgene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

A regulated, NFkappaB-assisted import of plasmid DNA into mammalian cell nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

Immunization through dermal delivery of protein-encoding DNA: a role for migratory dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

Expression of TNF-alpha by herpes simplex virus-infected macrophages is regulated by a dual mechanism: transcriptional regulation by NF-kappa B and activating transcription factor 2/Jun and translational regulation through the AU-rich region of the

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

TNFalpha and IFNgamma induced by innate anti-adenoviral immune responses inhibit adenovirus-mediated transgene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

Repression of retrovirus-mediated transgene expression by interferons: implications for gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302031

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6 August 2017

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