Sequestration of toxic oligomers by HspB1 as a cytoprotective mechanism (Q35139418)

6 August 2017

Sequestration of toxic oligomers by HspB1 as a cytoprotective mechanism (English)

1 reference

6 August 2017

Juhi Ojha

1

1 reference

6 August 2017

Gunasingh Masilamoni

2

1 reference

6 August 2017

David Dunlap

3

1 reference

6 August 2017

Ross A Udoff

4

1 reference

6 August 2017

Anil G Cashikar

5

1 reference

6 August 2017

language of work or name

English

0 references

publication date

13 June 2011

1 reference

Molecular and Cellular Biology

6 August 2017

1 reference

6 August 2017

31

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6 August 2017

15

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6 August 2017

3146-3157

1 reference

describes a project that uses

6 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3147607/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Cellular strategies for controlling protein aggregation

13 July 2018

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Chaperone networks: tipping the balance in protein folding diseases

13 July 2018

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Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability

13 July 2018

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Alzheimer's disease and the amyloid-beta peptide

13 July 2018

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Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

13 July 2018

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Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

13 July 2018

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Phosphorylation dependence of hsp27 multimeric size and molecular chaperone function

13 July 2018

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Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

13 July 2018

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Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1

13 July 2018

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Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

13 July 2018

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The insulin paradox: aging, proteotoxicity and neurodegeneration

13 July 2018

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Structural classification of toxic amyloid oligomers

13 July 2018

1 reference

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

13 July 2018

1 reference

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Chaperone-dependent amyloid assembly protects cells from prion toxicity

13 July 2018

1 reference

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Extrinsic fluorescent dyes as tools for protein characterization

13 July 2018

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Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption

13 July 2018

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The cellular "networking" of mammalian Hsp27 and its functions in the control of protein folding, redox state and apoptosis

13 July 2018

1 reference

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Small heat shock proteins differentially affect Abeta aggregation and toxicity.

13 July 2018

1 reference

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A specific amyloid-beta protein assembly in the brain impairs memory

13 July 2018

1 reference

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Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies

13 July 2018

1 reference

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Protein quality in bacterial inclusion bodies.

13 July 2018

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Transgenic models of Alzheimer's disease: learning from animals

13 July 2018

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Some like it hot: the structure and function of small heat-shock proteins.

13 July 2018

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AlphaB-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid beta-peptide and beta2-microglobulin

13 July 2018

1 reference

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Induction of heat shock proteins in B-cell exosomes.

13 July 2018

1 reference

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Small heat shock proteins: a new classification scheme in mammals

13 July 2018

1 reference

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Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

13 July 2018

1 reference

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Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain

13 July 2018

1 reference

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Evolutionary diversity of vertebrate small heat shock proteins.

13 July 2018

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Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy

13 July 2018

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HSP27 but not HSP70 has a potent protective effect against alpha-synuclein-induced cell death in mammalian neuronal cells.

13 July 2018

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Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology

13 July 2018

1 reference

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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

13 July 2018

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

13 July 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

13 July 2018

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In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

13 July 2018

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sHsps and their role in the chaperone network

13 July 2018

1 reference

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Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

13 July 2018

1 reference

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Alpha-crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Structure and function of small heat shock/alpha-crystallin proteins: established concepts and emerging ideas

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Intraneuronal Abeta42 accumulation in human brain.

13 July 2018

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Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Crystal structure of a small heat-shock protein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Alpha B crystallin and HSP28 are enhanced in the cerebral cortex of patients with Alzheimer's disease.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Expression of alpha B-crystallin in Alzheimer's disease.

13 July 2018

1 reference

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Heat shock factor and the heat shock response

13 July 2018

1 reference

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Alpha-crystallin can function as a molecular chaperone

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Astrocytic A beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteins

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

The small heat shock protein Hsp27 protects cortical neurons against the toxic effects of beta-amyloid peptide.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Over expression of amyloid beta-protein reduces the number of neurons in the striatum of APPswe/PS1DeltaE9.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Amyloid-like properties of bacterial inclusion bodies.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Inhibition of amyloid fibrillogenesis and toxicity by a peptide chaperone

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Constitutive expression of heat shock protein HSP25 in the central nervous system of the developing and adult mouse.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Staining methods for identification of amyloid in tissue

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Dementia, gliosis and expression of the small heat shock proteins hsp27 and alpha B-crystallin in Parkinson's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

The small heat-shock protein, alphaB-crystallin, has a variable quaternary structure

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147607

Small heat shock proteins inhibit in vitro A beta(1-42) amyloidogenesis

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21670152

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21670152

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.01187-10

1 reference

6 August 2017

1 reference

6 August 2017

1 reference