CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells (Q35143070)

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English	CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells	scientific article

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13 March 2020

CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells (English)

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13 March 2020

Mycobacterium bovis

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13 March 2020

Tom H M Ottenhoff

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Tom H M Ottenhoff

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13 March 2020

Krista E van Meijgaarden

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Krista E van Meijgaarden

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13 March 2020

Simone A Joosten

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Simone A Joosten

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8 April 2014

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13 March 2020

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13 March 2020

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13 March 2020

e94192

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13 March 2020

4

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13 March 2020

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Creative Commons Attribution 4.0 International

8 April 2014

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Increased frequency of myeloid-derived suppressor cells during active tuberculosis and after recent mycobacterium tuberculosis infection suppresses T-cell function

1 reference

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28 July 2018

CD39 is involved in mediating suppression by Mycobacterium bovis BCG-activated human CD8(+) CD39(+) regulatory T cells.

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Vaccines against tuberculosis: where are we and where do we need to go?

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Imbalance of Th17 cells and regulatory T cells in tuberculous pleural effusion

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The immune responses of central and effector memory BCG-specific CD4+ T cells in BCG-vaccinated PPD+ donors were modulated by Treg cells

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Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity

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Characterization of regulatory T cells identified as CD4(+)CD25(high)CD39(+) in patients with active tuberculosis

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Retracted: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection

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Human CD4 and CD8 regulatory T cells in infectious diseases and vaccination

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28 July 2018

CD8+ suppressor T cells resurrected.

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Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases

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Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination

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Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.

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Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis

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IL-10-producing T cells suppress immune responses in anergic tuberculosis patients

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Cloned suppressor T cells from a lepromatous leprosy patient suppress Mycobacterium leprae reactive helper T cells

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Lack of Mycobacterium tuberculosis-specific interleukin-17A-producing CD4+ T cells in active disease

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21 January 2018

Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection

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Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cells.

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Regulatory T cells depress immune responses to protective antigens in active tuberculosis

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Regulatory T cells attenuate mycobacterial stasis in alveolar and blood-derived macrophages from patients with tuberculosis.

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Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A.

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The Achilles heel of BCG.

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Human plasmacytoid dendritic cells induce CD8⁺ LAG-3⁺ Foxp3⁺ CTLA-4⁺ regulatory T cells that suppress allo-reactive memory T cells.

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Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers

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Neonatal mycobacterial specific cytotoxic T-lymphocyte and cytokine profiles in response to distinct BCG vaccination strategies

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Genetically restricted suppressor T-cell clones derived from lepromatous leprosy lesions

1 reference

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Bacillus Calmette Guerin vaccination of human newborns induces a specific, functional CD8+ T cell response

1 reference

https://pubmed.ncbi.nlm.nih.gov/24714620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neonatal BCG vaccination induces IL-10 production by CD4+ CD25+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24714620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mycobacterium tuberculosis-specific CD8+T cells are functionally and phenotypically different between latent infection and active disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24714620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0094192

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13 March 2020

2014PLoSO...994192B

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1 reference

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13 March 2020

1 reference

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13 March 2020

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