Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma (Q35143496)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21712538%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma (English)

1 reference

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6 February 2020

main subject

phenethyl isothiocyanate

1 reference

ChEBI release 2020-05-28

4

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6 February 2020

author name string

Jana Jakubikova

1

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6 February 2020

David Cervi

2

1 reference

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6 February 2020

Melissa Ooi

3

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6 February 2020

Sabikun Nahar

5

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6 February 2020

Steffen Klippel

6

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6 February 2020

Dana Cholujova

7

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6 February 2020

Merav Leiba

8

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6 February 2020

John F Daley

9

1 reference

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6 February 2020

Jake Delmore

10

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6 February 2020

Joseph Negri

11

1 reference

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6 February 2020

Simona Blotta

12

1 reference

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6 February 2020

Douglas W McMillin

13

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6 February 2020

Teru Hideshima

14

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6 February 2020

Paul G Richardson

15

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6 February 2020

Jan Sedlak

16

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6 February 2020

Kenneth C Anderson

17

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6 February 2020

Constantine S Mitsiades

18

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6 February 2020

publication date

28 June 2011

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6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21712538%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

96

1 reference

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6 February 2020

issue

8

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6 February 2020

page(s)

1170-1179

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21712538%20AND%20SRC:MED&resulttype=core&format=json

Glucosinolates in Brassica vegetables: the influence of the food supply chain on intake, bioavailability and human health.

6 February 2020

cites work

1 reference

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Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells

13 July 2018

1 reference

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

13 July 2018

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Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model

13 July 2018

1 reference

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Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib

13 July 2018

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Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane

13 July 2018

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Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate

13 July 2018

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Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity

13 July 2018

1 reference

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Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148911

Multiple myeloma: a prototypic disease model for the characterization and therapeutic targeting of interactions between tumor cells and their local microenvironment

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148911

Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148911

Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148911

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

13 July 2018

1 reference

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Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations

13 July 2018

1 reference

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Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications

13 July 2018

1 reference

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Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells.

13 July 2018

1 reference

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E-cadherin and its downstream catenins are proteolytically cleaved in human HaCaT keratinocytes exposed to UVB.

13 July 2018

1 reference

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beta-Phenylethyl isothiocyanate mediated apoptosis: a proteomic investigation of early apoptotic protein changes.

13 July 2018

1 reference

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

13 July 2018

1 reference

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Selected isothiocyanates rapidly induce growth inhibition of cancer cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148911

Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization

13 July 2018

1 reference

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Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148911

Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148911

Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148911

Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148911

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

13 July 2018

1 reference

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

13 July 2018

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De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc

13 July 2018

1 reference

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Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells

27 September 2018

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Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

27 September 2018

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Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli.

27 September 2018

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Effects of MEK1 and PI3K inhibitors on allyl-, benzyl- and phenylethyl-isothiocyanate-induced G2/M arrest and cell death in Caco-2 cells.

27 September 2018

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Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells

27 September 2018

1 reference

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Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro

27 September 2018

1 reference

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Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

27 September 2018

1 reference

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Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148911

Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21712538

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21712538

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21712538

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3324/HAEMATOL.2010.029363

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21712538%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21712538%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

21712538

1 reference