Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth. (Q35145016)

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English	Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.	scientific article

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2 February 2020

Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth (English)

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2 February 2020

Leishmania mexicana

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Leishmania mexicana

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2 February 2020

Eleanor Saunders

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Eleanor C Saunders

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2 February 2020

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William W Ng

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Jennifer M Chambers

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Milica Ng

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Thomas Naderer

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Vladimir A Likic

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Malcolm J McConville

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2 June 2011

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Journal of Biological Chemistry

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27706-27717

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2 February 2020

Evidence that intracellular stages of Leishmania major utilize amino sugars as a major carbon source

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28 July 2018

Ablation of succinate production from glucose metabolism in the procyclic trypanosomes induces metabolic switches to the glycerol 3-phosphate/dihydroxyacetone phosphate shuttle and to proline metabolism.

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Retracted: Branched tricarboxylic acid metabolism in Plasmodium falciparum

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Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence

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Carbon metabolism of intracellular bacterial pathogens and possible links to virulence

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Central carbon metabolism of Leishmania parasites

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Surprising variety in energy metabolism within Trypanosomatidae

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Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes

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Carbon metabolism of Listeria monocytogenes growing inside macrophages

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Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major

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28 July 2018

Metabolic functions of glycosomes in trypanosomatids

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Fumarate is an essential intermediary metabolite produced by the procyclic Trypanosoma brucei

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28 July 2018

Leishmania beta-1,2-mannan is assembled on a mannose-cyclic phosphate primer.

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28 July 2018

Energy metabolism of trypanosomatids: adaptation to available carbon sources

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28 July 2018

Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase

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28 July 2018

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New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle.

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ATP generation in the Trypanosoma brucei procyclic form: cytosolic substrate level is essential, but not oxidative phosphorylation.

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28 July 2018

Genetic characterization of glucose transporter function in Leishmania mexicana

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28 July 2018

Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase

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28 July 2018

Characterisation of phosphoglycerate kinase genes in Leishmania major and evidence for the absence of a third closely related gene or isoenzyme.

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28 July 2018

Adaptation of metabolic enzyme activities of Trypanosoma brucei promastigotes to growth rate and carbon regimen.

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28 July 2018

Mortality of Leishmania major in Phlebotomus papatasi caused by plant feeding of the sand flies.

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Studies on the amino acids of the tsetse fly, Glossina morsitans, maintained on in vitro and in vivo feeding systems.

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28 July 2018

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28 July 2018

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28 July 2018

Molecular analysis of the cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase in Leishmania mexicana

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Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi.

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27 September 2018

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27 September 2018

(13)C-based metabolic flux analysis.

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Active transport of glutamate in Leishmania (Leishmania) amazonensis

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Role of hexosamine biosynthesis in Leishmania growth and virulence

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27 September 2018

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Purine and pyrimidine metabolism in Leishmania

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27 September 2018

A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania.

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27 September 2018

The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp.

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27 September 2018

Progressive peak clustering in GC-MS Metabolomic experiments applied to Leishmania parasites.

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27 September 2018

Acetyl:succinate CoA-transferase in procyclic Trypanosoma brucei. Gene identification and role in carbohydrate metabolism

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27 September 2018

Pentose phosphate metabolism in Leishmania mexicana

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27 September 2018

Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites

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27 September 2018

Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation

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27 September 2018

Developmental regulation of proline transport in Leishmania donovani.

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27 September 2018

Organization, sequence and stage-specific expression of the phosphoglycerate kinase genes of Leishmania mexicana mexicana.

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27 September 2018

Leishmania mexicana: Subcellular distribution of enzymes in amastigotes and promastigotes

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21 January 2018

Leishmania mexicana: energy metabolism of amastigotes and promastigotes

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12 December 2020

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12 December 2020

based on heuristic

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Inhibition of the respiratory chain results in a reversible metabolic arrest in Leishmania promastigotes

1 reference

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12 December 2020

based on heuristic

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Isolation and partial characterization of a broad specificity aminotransferase from Leishmania mexicana promastigotes

1 reference

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Leishmania spp: completely defined medium without serum and macromolecules (CDM/LP) for the continuous in vitro cultivation of infective promastigote forms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21636575

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based on heuristic

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10.1074/JBC.M110.213553

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2 February 2020

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2 February 2020

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2 February 2020

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