The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells (Q35151541)

6 August 2017

title

The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells (English)

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6 August 2017

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Qi Wu

1

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6 August 2017

Yu Liu

2

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6 August 2017

Chong Chen

3

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6 August 2017

Tsuneo Ikenoue

4

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6 August 2017

Yu Qiao

5

1 reference

6 August 2017

Chi-Shan Li

6

1 reference

6 August 2017

Weiquan Li

7

1 reference

6 August 2017

Kun-Liang Guan

8

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6 August 2017

Yang Liu

9

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6 August 2017

Pan Zheng

10

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6 August 2017

language of work or name

English

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publication date

27 June 2011

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6 August 2017

published in

Journal of Immunology

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6 August 2017

volume

187

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6 August 2017

issue

3

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6 August 2017

page(s)

1106-1112

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Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice.

6 August 2017

cites work

1 reference

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mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

13 July 2018

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Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels

13 July 2018

1 reference

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Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors

13 July 2018

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mTOR regulates memory CD8 T-cell differentiation

13 July 2018

1 reference

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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

13 July 2018

1 reference

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

13 July 2018

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Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection

13 July 2018

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Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

13 July 2018

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TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

13 July 2018

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Regulation of TORC1 by Rag GTPases in nutrient response

13 July 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

13 July 2018

1 reference

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The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

13 July 2018

1 reference

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Generation of gut-homing T cells and their localization to the small intestinal mucosa

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Complexity of the TOR signaling network

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

13 July 2018

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

How alpha beta T cells deal with induced TCR alpha ablation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Peripheral T cell survival

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Immunopharmacology of rapamycin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

CD8+ T cell contraction is controlled by early inflammation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151493

Apoptotic thymocyte clearance in scavenger receptor class A-deficient mice is apparently normal

8 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21709159

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21709159

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4049/JIMMUNOL.1003968

1 reference

6 August 2017

1 reference

6 August 2017

1 reference