Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes (Q35152836)

6 August 2017

Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes (English)

1 reference

6 August 2017

Zi-Qiang Zhou

1

1 reference

6 August 2017

Sara Ota

2

1 reference

6 August 2017

Chuxia Deng

3

1 reference

6 August 2017

Haruhiko Akiyama

4

1 reference

6 August 2017

Peter J Hurlin

5

1 reference

6 August 2017

28 November 2014

1 reference

6 August 2017

Human Molecular Genetics

1 reference

6 August 2017

24

1 reference

6 August 2017

6

1 reference

6 August 2017

1764-1773

1 reference

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

The chondrocytic journey in endochondral bone growth and skeletal dysplasia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Development of the endochondral skeleton

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Runx2 protein stabilizes hypoxia-inducible factor-1α through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Generation of transgenic mice for conditional overexpression of Sox9

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

FGFs in endochondral skeletal development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Dominance of SOX9 function over RUNX2 during skeletogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

FGF signaling in the developing endochondral skeleton

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repair

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Cbfa1 is a positive regulatory factor in chondrocyte maturation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Sox9 is required for cartilage formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Regulation of chondrocyte differentiation by Cbfa1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Fibroblast growth factor receptor 3 is a negative regulator of bone growth

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Detection of messenger RNA using a digoxigenin end labelled oligodeoxynucleotide probe

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Homozygous achondroplasia: morphologic and biochemical study of cartilage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351382

Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.

28 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

Delayed bone age due to a dual effect of FGFR3 mutation in Achondroplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

Disruption of a Sox9-β-catenin circuit by mutant Fgfr3 in thanatophoric dysplasia type II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

Interactions between Sox9 and beta-catenin control chondrocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

Inhibition of beta-catenin signaling causes defects in postnatal cartilage development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU594

Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25432534

12 December 2020

inferred from PubMed ID database lookup

Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25432534

12 December 2020

inferred from PubMed ID database lookup

Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25432534

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/HMG/DDU594

1 reference

release_q3q3zqpivfcixck3mzablrftia

6 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/q3q3zqpivfcixck3mzablrftia

24 November 2022

mapped directly with Wikidata item

PMCID

4351382

1 reference

6 August 2017

1 reference