Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite (Q35156257)

6 August 2017

Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite (English)

1 reference

6 August 2017

1 reference

Katrina A Button-Simons

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Richard S. Pinapati

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Geoffrey H Siwo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Asako Tan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Upeka Samarakoon

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Lisa A Checkley

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Michael T Ferdig

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

language of work or name

English

0 references

publication date

22 February 2015

1 reference

6 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

6 June 2020

copyright license

start time

22 February 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/s12864-015-1261-6

0 references

cites work

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Metabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolism

13 July 2018

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Key genes for modulating information flow play a temporal role as breast tumor coexpression networks are dynamically rewired by letrozole

13 July 2018

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Emerging artemisinin resistance in the border areas of Thailand

13 July 2018

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Epigenetic epistatic interactions constrain the evolution of gene expression

13 July 2018

1 reference

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Beyond differential expression: the quest for causal mutations and effector molecules

13 July 2018

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A single source k-shortest paths algorithm to infer regulatory pathways in a gene network

13 July 2018

1 reference

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Predicting mutation outcome from early stochastic variation in genetic interaction partners.

13 July 2018

1 reference

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Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets

13 July 2018

1 reference

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Coupled evolution of transcription and mRNA degradation

13 July 2018

1 reference

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CCR4-associated factor 1 coordinates the expression of Plasmodium falciparum egress and invasion proteins

13 July 2018

1 reference

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Predicting selective drug targets in cancer through metabolic networks.

13 July 2018

1 reference

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H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3

13 July 2018

1 reference

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The Apicomplexan AP2 family: integral factors regulating Plasmodium development

13 July 2018

1 reference

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Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite

13 July 2018

1 reference

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Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network.

13 July 2018

1 reference

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From 'differential expression' to 'differential networking' - identification of dysfunctional regulatory networks in diseases

13 July 2018

1 reference

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A decade of epigenetic research in Toxoplasma gondii

13 July 2018

1 reference

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Need-based up-regulation of protein levels in response to deletion of their duplicate genes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum

13 July 2018

1 reference

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Chloroquine transport via the malaria parasite's chloroquine resistance transporter

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

A differential wiring analysis of expression data correctly identifies the gene containing the causal mutation.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Regulatory hotspots in the malaria parasite genome dictate transcriptional variation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

MADIBA: a web server toolkit for biological interpretation of Plasmodium and plant gene clusters

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Widespread genetic incompatibility in C. elegans maintained by balancing selection

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Conservation and evolution of gene coexpression networks in human and chimpanzee brains

13 July 2018

1 reference

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Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria

13 July 2018

1 reference

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Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems

13 July 2018

1 reference

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Influence of metabolic network structure and function on enzyme evolution

13 July 2018

1 reference

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The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

A protein interaction network of the malaria parasite Plasmodium falciparum

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Reverse engineering of regulatory networks in human B cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Dissecting the loci of low-level quinine resistance in malaria parasites

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Global control of gene expression in yeast by the Ccr4-Not complex

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

The CCR4-NOT complex plays diverse roles in mRNA metabolism

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Predicting gene function by conserved co-expression

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Chloroquine resistance and the pH of the malaria parasite's digestive vacuole.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

A statistical framework for quantitative trait mapping.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Modifier genes in mice and humans

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Phenotypes of patients with "simple" Mendelian disorders are complex traits: thresholds, modifiers, and systems dynamics

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Monogenic traits are not simple: lessons from phenylketonuria

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Variations in frequencies of drug resistance in Plasmodium falciparum

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Arabidopsis thaliana CBF1 encodes an AP2 domain-containing transcriptional activator that binds to the C-repeat/DRE, a cis-acting DNA regulatory element that stimulates transcription in response to low temperature and water deficit

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Empirical threshold values for quantitative trait mapping

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Malaria. How chloroquine works.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

An integrative approach for causal gene identification and gene regulatory pathway inference

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Reconstructing biological networks using conditional correlation analysis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Finding disease specific alterations in the co-expression of genes.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Gene co-expression network topology provides a framework for molecular characterization of cellular state

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Caenorhabditis elegans T-box genes tbx-9 and tbx-8 are required for formation of hypodermis and body-wall muscle in embryogenesis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352545

Phenotypic diversity, allelic series and modifier genes

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FS12864-015-1261-6

Exposing the fitness contribution of duplicated genes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25765049

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S12864-015-1261-6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 June 2020

1015302049

0 references

Fatcat ID

release_4ydrx2tizvg6xltmvoceiwse4a

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4ydrx2tizvg6xltmvoceiwse4a

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25765049%20AND%20SRC:MED&resulttype=core&format=json